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Résumé Les ASIC forment des canaux cationiques activés par une acidification du milieu extracellulaire, qui sont récemment apparus comme des senseurs importants du proton extracellulaire dans le système nerveux central et dans le système nerveux périphérique. Le rôle de ces canaux dans la nociception semble impliquer différentes isoformes à plusieurs niveaux: ASIC3 dans les neurones sensoriels et...
Acid sensing ion channel 3 (ASIC3) is a cation channel gated by extracellular protons. It is highly expressed in sensory neurons, including small nociceptive neurons and has been proposed to participate in pain perception associated with tissue acidosis and in mechanoperception. Neuropeptide FF (NPFF) and FMRFamide have been shown to potentiate proton-gated currents from cultured sensory neurons and...
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