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SUMOs are Small Ubiquitin-like Modifiers that are covalently conjugated to extensive sets of target proteins in cells to regulate their activity. A properly functioning sumoylation system is essential for eukaryotic life. The system comprises a set of conjugating enzymes known as E1, E2 and E3s and a set of deconjugating enzymes known as SENPs. Three mammalian SUMO family members have been identified,...