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The pleomorphic xanthoastrocytoma (PXA) is a unique astrocytic neoplasm with an unexpectedly favorableprognosis despite striking pleomorphism of the cellular constituents. Although a majority of patients experi-enceextended survival, these tumors may recur and some cases progress to high-grade astrocytoma. Recur-renceinevitably involves the anatomic vicinity of the primary tumor. In this report, we...
Malignant gliomas continue to be a significant sourceof mortality in young and middle aged adults.The introduction of new treatment strategies and multidisciplinaryapproaches has improved the outcome of patients withthese tumors only slightly. Because retinoic acid hasgrowth inhibitory activity against glioma and neuroblastoma cellsin cultures, we assessed the efficacy of all-trans-retinoicacid in...
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