Search results for: Velidi H. Rao

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article

Data on TREM-1 activation destabilizing carotid plaques

Velidi H. Rao, Vikrant Rai, Samantha Stoupa, Saravanan Subramanian, more

Data in Brief > 2016 > 8 > C > 230-234

The data described herein are related to the article entitled “Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis” (Rao et al., 2016) [1]. Additional data are provided on the dose–response effect of TNF-α, TREM-1 antibody and recombinant rTREM-1/Fc fusion chimera...

article

Tumor necrosis factor-α regulates triggering receptor expressed on myeloid cells-1-dependent matrix metalloproteinases in the carotid plaques of symptomatic patients with carotid stenosis

Velidi H. Rao, Vikrant Rai, Samantha Stoupa, Saravanan Subramanian, more

Atherosclerosis > 2016 > 248 > C > 160-169

To determine the relationship between increased triggering receptor expressed on myeloid cells (TREM)-1 and plaque stability in atherosclerotic carotid stenosis.The mRNA transcripts and protein for TREM-1, MMP-1, MMP-9, collagen type I (COL1A1) and collagen type III (COL3A1) were analyzed by qPCR and immunofluorescence in both tissues and VSMCs isolated from atherosclerotic carotid plaques of symptomatic...

article

Erbb2 up‐regulation of ADAM12 expression accelerates skin cancer progression

Velidi H. Rao, Kristen Vogel, Jodi K. Yanagida, Nitin Marwaha, more

Molecular Carcinogenesis > 54 > 10 > 1026 - 1036

Solar ultraviolet (UV) radiation can cause severe damage to the skin and is the primary cause of most skin cancer. UV radiation causes DNA damage leading to mutations and also activates the Erbb2/HER2 receptor through indirect mechanisms involving reactive oxygen species. We hypothesized that Erbb2 activation accelerates the malignant progression of UV‐induced skin cancer. Following the induction...

article

Implications for Alport Syndrome

Dominic Cosgrove, Daniel T. Meehan, Duane Delimont, Ambra Pozzi, more

The American Journal of Pathology > 2008 > 172 > 3 > 761-773

Previous work has shown that integrin α1-null Alport mice exhibit attenuated glomerular disease with decreased matrix accumulation and live much longer than strain-matched Alport mice. However, the mechanism underlying this observation is unknown. Here we show that glomerular gelatinase expression, specifically matrix metalloproteinase-2 (MMP-2), MMP-9, and MMP-14, was significantly elevated in both...

article

Role for Macrophage Metalloelastase in Glomerular Basement Membrane Damage Associated with Alport Syndrome

Velidi H. Rao, Daniel T. Meehan, Duane Delimont, Motowo Nakajima, more

The American Journal of Pathology > 2006 > 169 > 1 > 32-46

Alport syndrome is a glomerular basement membrane (GBM) disease caused by mutations in type IV collagen genes. A unique irregular thickening and thinning of the GBM characterizes the progressive glomerular pathology. The metabolic imbalances responsible for these GBM irregularities are not known. Here we show that macrophage metalloelastase (MMP-12) expression is >40-fold induced in glomeruli from...

article

Implications for Capillary Basement Membrane Pathology

Michael Anne Gratton, Velidi H. Rao, Daniel T. Meehan, Charles Askew, more

The American Journal of Pathology > 2005 > 166 > 5 > 1465-1474

Alport syndrome results from mutations in genes encoding collagen α3(IV), α4(IV), or α5(IV) and is characterized by progressive glomerular disease associated with a high-frequency sensorineural hearing loss. Earlier studies of a gene knockout mouse model for Alport syndrome noted thickening of strial capillary basement membranes in the cochlea, suggesting that the stria vascularis is the primary site...

article

Dysregulation of renal MMP-3 and MMP-7 in canine X-linked Alport syndrome

Velidi H. Rao, George E. Lees, Clifford E. Kashtan, Duane C. Delimont, more

Pediatric Nephrology > 2005 > 20 > 6 > 732-739

Matrix metalloproteinases (MMPs) play an important regulatory role in many biological and pathological processes and their specific role in Alport syndrome (AS) is not yet clearly defined. In this study, the naturally occurring canine X-linked AS was used to demonstrate a potential role for MMP-3 and MMP-7 in Alport renal pathogenesis. Recently, we demonstrated that the expression of MMP-2, MMP-9...

article

Accelerated Linear Growth and Advanced Bone Age in Sotos Syndrome is Not Associated with Abnormalities of Collagen Metabolism - Compiled data of 22 cases. Analysis of clinical features, growth and plasma somatomedin

Velidi H. Rao, Bruce A. Buehler, G. Bradley Schaefer

Clinical Biochemistry > 1998 > 31 > 4 > 241-249

Objectives: To investigate whether the advanced bone age in Sotos syndrome is associated with alterations in type I collagen metabolism in bone.Design and methods: The metabolism of collagen was studied by analyzing the production, gene expression and degradation of type I collagen in dermal fibroblast strains from patients with Sotos syndrome and comparing them with fibroblasts from age-matched healthy...

article

Regulation of MMP-9 (92 kDa type IV collagenase/gelatinase B) expression in stromal cells of human giant cell tumor of bone

Velidi H. Rao, Rakesh K. Singh, Julia A. Bridge, James R. Neff, more

Clinical & Experimental Metastasis > 1997 > 15 > 4 > 400-409

Matrix metalloproteinases (MMPs) play an important regulatory role in tissue morphogenesis, cell differentiation, tumor invasion and metastasis. Several authors have reported a direct correlation between the production of 72 kDa (MMP-2) and 92 kDa (MMP-9) type IV collagenases/gelatinases and the metastatic potential of cancer cells. Recently, we have identified the expression of both MMP-2 and MMP-9...

article

Intracellular degradation of newly synthesized collagen is conformation-dependent - Studies in human skin fibroblasts

Beat Steinmann, Velidi H. Rao, Richard Gitzelmann

FEBS Letters > 1981 > 133 > 1 > 142-144

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Keywords

ATHEROSCLEROSIS (2)
MATRIX METALLOPROTEINASES (2)
TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS-1 (2)
ADAM12 (1)
CAROTID PLAQUES (1)
COLLAGEN DEGRADATION (1)
COLLAGEN METABOLISM (1)
COLLAGEN PRODUCTION (1)
COLLAGEN TURNOVER (1)
CYTOKINES (1)
ERBB2/HER2 (1)
EXTRACELLULAR MATRIX (1)
FIBROBLASTS (1)
GENE EXPRESSION (1)
GIANT CELL TUMOR (1)
INFLAMMATION (1)
KIDNEY FIBROSIS (1)
MACROPHAGES (1)
MATRILYSIN (1)
MATRIX METALLOPROTEINASE (1)
METALLOPROTEINASES (1)
NONMELANOMA SKIN CANCER (1)
RT-PCR (1)
SDS-PAGE (1)
SOTOS SYNDROME (1)
STROMAL CELLS (1)
STROMELYSIN-1 (1)
TRANSCRIPTION FACTORS (1)
TUMOR NECROSIS FACTOR-Α (1)
TUMOR PROGRESSION (1)
TYPE I COLLAGEN (1)
ULTRAVIOLET IRRADIATION (1)
UNSTABLE PLAQUE (1)
VASCULAR SMOOTH MUSCLE CELLS (1)
VULNERABLE PLAQUE (1)
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Elsevier (7)
Springer (2)
Wiley (1)

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Search results for: Velidi H. Rao

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