Search results for: Mark A. Smith

Items from 1 to 20 out of 422 results

article

P‐28: Investigating the Usability of Touchscreen Interfaces in a Turbulent Flight Deck – For Panning and Numeric Data Entry Tasks

Mark A. Smith, Katherine L. Plant, Katie J. Parnell, Rachael A. Wynne, more

SID Symposium Digest of Technical Papers > 51 > 1 > 1438 - 1441

This paper studies the use of touchscreen displays on the flight deck, focusing on the usability of touch interfaces to complete panning and numeric entry tasks. Results from this study show that the usability of a drag gesture to meet a pan function, surpasses the performance of a simple tapping interface under all turbulent conditions tested. Also, that this drag interface is more useable in an...

article

2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols with Unusual Acyl Composition in Seed Oils of the Genus Polygala

Mark A. Smith, Haixia Zhang, Ian W. Burton, Chao Liu, more

European Journal of Lipid Science and Technology > 120 > 8 > n/a - n/a

Seed oils containing unusual triacylglycerol (TAG) molecules, where one fatty acid of a TAG is substituted by an acetate group (Ac), are uncommon but of considerable interest as potential low‐viscosity biofuels and lubricants or reduced calorie food ingredients. Although the properties and pathway of biosynthesis of 3‐acetyl‐1,2‐diacyl‐sn‐glycerols (sn‐3‐acTAGs) have been described, little is known...

article

Pathways of unauthorized fish introductions and types of management responses

Frank J. Rahel, Mark A. Smith

Hydrobiologia > 2018 > 817 > 1 > 41-56

Unauthorized introductions are an ongoing problem for fisheries managers. To understand reasons for the continued spread of nonnative fish species, the pathways of nonnative fish introductions were analyzed from 1961 to 2017 in Wyoming, USA. Unauthorized introductions are those that occurred without oversight of a management agency. The largest source of unauthorized introductions was the deliberate,...

article

Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats

Mark A. Smith, Gaylen E. Fronk, Jean M. Abel, Ryan T. Lacy, more

Psychopharmacology > 2018 > 235 > 4 > 1245-1255

Rationale Preclinical studies consistently report that aerobic exercise decreases drug self-administration and other forms of drug-seeking behavior; however, relatively few studies have examined other types of physical activity. Objectives The purpose of the present study was to examine the effects of resistance exercise (i.e., strength training) on heroin self-administration and mRNA expression...

article

Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States

Paulius Viskaitis, Elaine E. Irvine, Mark A. Smith, Agharul I. Choudhury, more

Cell Reports > 2017 > 21 > 12 > 3559-3572

Feeding requires the integration of homeostatic drives with emotional states relevant to food procurement in potentially hostile environments. The ventromedial hypothalamus (VMH) regulates feeding and anxiety, but how these are controlled in a concerted manner remains unclear. Using pharmacogenetic, optogenetic, and calcium imaging approaches with a battery of behavioral assays, we demonstrate that...

article

Improving chances for successful clinical outcomes with better preclinical models

Heather Wenzel, Robert W. Kaminski, Kristen A. Clarkson, Milton Maciel, more

Vaccine > 2017 > 35 > 49(PA) > 6798-6802

In order to avoid expensive clinical failures, better and more predictive animal models of vaccine efficacy are needed to screen Shigella and ETEC vaccine candidates for protective efficacy. The 2016 Vaccines Against Shigella and ETEC (VASE) Conference included a workshop focused on the strengths and weaknesses of current models, particularly in terms of the correlation to vaccine efficacy in human...

article

Exercise as a Prevention for Substance Use Disorder: a Review of Sex Differences and Neurobiological Mechanisms

Wendy J. Lynch, Andrea M. Robinson, Jean Abel, Mark A. Smith

Current Addiction Reports > 2017 > 4 > 4 > 455-466

Purpose of Review This report provides an update on clinical and preclinical findings for the efficacy of exercise to prevent substance use disorder with a focus on recent evidence for sex differences and neurobiological mechanisms. Recent Findings Exercise/physical activity is associated with decreased drug use in humans. Preclinical results further indicate that exercise decreases vulnerability...

article

Exercise as a Sex-Specific Treatment for Substance Use Disorder

Wendy J. Lynch, Jean Abel, Andrea M. Robinson, Mark A. Smith

Current Addiction Reports > 2017 > 4 > 4 > 467-481

Purpose of Review Exercise is a promising treatment for substance use disorder that may reduce withdrawal symptoms and prevent relapse. In this review, we discuss recent evidence from clinical and preclinical studies for its efficacy, from a behavioral to a molecular level, in order to understand the exercise conditions that lead to beneficial effects. We also highlight the few recent findings of...

article

Pharmacokinetics and Safety of Single‐Dose Inhaled Loxapine in Children and Adolescents

Sally Selim, Robert Riesenberg, James Cassella, Jeevan Kunta, more

The Journal of Clinical Pharmacology > 57 > 10 > 1244 - 1257

This multisite open‐label study sought to characterize the pharmacokinetics and safety of a single dose of inhaled loxapine in children and adolescents. Loxapine powder for oral inhalation was administered via a single‐use handheld drug device to children and adolescents (aged 10–17 years) with any condition warranting chronic antipsychotic use. Patients were dosed according to body weight and cohort...

article

The effects of social contact on cocaine intake in female rats

Andrea M. Robinson, Gaylen E. Fronk, Huailin Zhang, Scott Tonidandel, more

Drug and Alcohol Dependence > 2017 > 177 > C > 48-53

Studies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the effects of social contact on cocaine intake in female rats, (2) examine the behavioral mechanisms by which social contact influences cocaine intake, and (3) examine whether the estrous cycle moderates...

article

Identification of Crepenynic Acid in the Seed Oil of Atractylodes lancea and A. macrocephala

Jin-Yue Sun, Xu Guo, Mark A. Smith

Journal of the American Oil Chemists' Society > 2017 > 94 > 5 > 655-660

Atractylodes rhizome is widely used in traditional Chinese herbal medicine. Although the chemical composition of the root has been studied in detail, the oil content and fatty acid composition of the seeds of Atractylodes species have not been reported. Fatty acyl composition of seeds from Atractylodes lancea and A. macrocephala was determined by gas chromatography and mass spectrometry of fatty acid...

article

Corrigendum to “Animal models of resistance exercise and their application to neuroscience research” [J. Neurosci. Methods 273 (2016) 191–200]

Justin C. Strickland, Mark A. Smith

Journal of Neuroscience Methods > 2017 > 280 > C > 77

article

Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents

Min Dong, Tsuyoshi Fukuda, Sally Selim, Mark A. Smith, more

Clinical Pharmacokinetics > 2017 > 56 > 10 > 1207-1217

Background and Objectives Loxapine for inhalation is a drug-device combination product approved in adults for the acute treatment of agitation associated with schizophrenia or bipolar I disorder. The primary objective of this study was to develop a clinical trial protocol to support a phase I pharmacokinetic study in children aged 10 years and older. In addition, this report details the results of...

article

The effects of social contact on “binge” cocaine self-administration

Andrea M. Robinson, Ryan Lacy, Justin C. Strickland, Charlotte P. Magee, more

Drug and Alcohol Dependence > 2017 > 171 > C > e177-e178

article

Acute bouts of wheel running decrease cocaine self-administration: Influence of exercise output

Mark A. Smith, Gaylen E. Fronk, Huailin Zhang, Charlotte P. Magee, more

Pharmacology Biochemistry and Behavior > 2016 > 150-151 > C > 94-99

Exercise is associated with lower rates of drug use in human populations and decreases drug self-administration in laboratory animals. Most of the existing literature examining the link between exercise and drug use has focused on chronic, long-term exercise, and very few studies have examined the link between exercise output (i.e., amount of exercise) and drug self-administration. The purpose of...

article

Animal models of resistance exercise and their application to neuroscience research

Justin C. Strickland, Mark A. Smith

Journal of Neuroscience Methods > 2016 > 273 > C > 191-200

Numerous studies have demonstrated that participation in regular resistance exercise (e.g., strength training) is associated with improvements in mental health, memory, and cognition. However, less is known about the neurobiological mechanisms mediating these effects. The goal of this mini-review is to describe and evaluate the available animal models of resistance exercise that may prove useful for...

chapter

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

Roberto Rodrigues, David J. Bonda, George Perry, Rudy J. Castellani, more

Brain Protection in Schizophrenia, Mood and Cognitive Disorders > Neuroprotective Strategies and Mechanisms > 305-323

Brain aging is one of the most complex issues confronting researchers in neuroscience today. Nevertheless, research on the molecular biology of neurodegenerative disorders, particularly Alzheimer disease, has provided enormous progress in understanding the mechanisms that ultimately lead to the neuronal and glial malfunctions that ultimately damage neurons resulting in death. In this regard, one of...

chapter

Alzheimer Disease: Oxidative Stress and Compensatory Responses

Paula I. Moreira, Akihiko Nunomura, Xiongwei Zhu, Hyoung-Gon Lee, more

Contemporary Clinical Neuroscience > Oxidative Neural Injury > 109-120

Oxidative stress occurs early in the progression of Alzheimer disease, significantly before the development of the pathologic hallmarks, neurofibrillary tangles, and senile plaques. All classes of macromolecules are affected by oxidative stress leading, inevitably, to neuronal dysfunction. Extensive data from the literature support the notion that mitochondrial and metal abnormalities are key sources...

article

The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens

Justin C. Strickland, Jean M. Abel, Ryan T. Lacy, Joshua S. Beckmann, more

Drug and Alcohol Dependence > 2016 > 163 > C > 186-194

Exercise is associated with positive outcomes in drug abusing populations and reduces drug self-administration in laboratory animals. To date, most research has focused on aerobic exercise, and other types of exercise have not been examined. This study examined the effects of resistance exercise (strength training) on cocaine self-administration and BDNF expression, a marker of neuronal activation...

article

Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate

Darragh Downey, Arpan Dutta, Shane McKie, Gerard R. Dawson, more

European Neuropsychopharmacology > 2016 > 26 > 6 > 994-1003

Intravenous infusion of lanicemine (formerly AZD6765), a low trapping non-selective N-methyl-D-aspartate (NMDA) receptor antagonist, induces antidepressant effects with a similar time course to ketamine. We investigated whether a single dose lanicemine infusion would reproduce the previously reported decrease in subgenual anterior cingulate cortex (sgACC) activity evoked by ketamine, a potential mechanism...

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INFONA - science communication portal

Search results for: Mark A. Smith

P‐28: Investigating the Usability of Touchscreen Interfaces in a Turbulent Flight Deck – For Panning and Numeric Data Entry Tasks

2‐Acetyl‐1,3‐Diacyl–sn‐Glycerols with Unusual Acyl Composition in Seed Oils of the Genus Polygala

Pathways of unauthorized fish introductions and types of management responses

Resistance exercise decreases heroin self-administration and alters gene expression in the nucleus accumbens of heroin-exposed rats

Modulation of SF1 Neuron Activity Coordinately Regulates Both Feeding Behavior and Associated Emotional States

Improving chances for successful clinical outcomes with better preclinical models

Exercise as a Prevention for Substance Use Disorder: a Review of Sex Differences and Neurobiological Mechanisms

Exercise as a Sex-Specific Treatment for Substance Use Disorder

Pharmacokinetics and Safety of Single‐Dose Inhaled Loxapine in Children and Adolescents

The effects of social contact on cocaine intake in female rats

Identification of Crepenynic Acid in the Seed Oil of Atractylodes lancea and A. macrocephala

Corrigendum to “Animal models of resistance exercise and their application to neuroscience research” [J. Neurosci. Methods 273 (2016) 191–200]

Clinical Trial Simulations and Pharmacometric Analysis in Pediatrics: Application to Inhaled Loxapine in Children and Adolescents

The effects of social contact on “binge” cocaine self-administration

Acute bouts of wheel running decrease cocaine self-administration: Influence of exercise output

Animal models of resistance exercise and their application to neuroscience research

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

Alzheimer Disease: Oxidative Stress and Compensatory Responses

The effects of resistance exercise on cocaine self-administration, muscle hypertrophy, and BDNF expression in the nucleus accumbens

Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate

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