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Reserpine inhibited batrachotoxin-elicited sodium influx in guinea pig brain synaptoneurosomes with an IC50 of about 1 μM. In the presence of brevetoxin the IC50 increased to about 80 μM. Reserpine inhibited binding of batrachotoxinin-A [3H]benzoate ([3H]BTX-B) binding in a complex manner causing a partial inhibition from 0.001 to 0.08 μM, then a rebound stimulation from 0.1 to 0.8 μM, followed by...