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The appearance of highly resistant bacterial biofilms in both community and hospitals environments is a major challenge in modern clinical medicine. The biofilm structural morphology, believed to be an important factor affecting the behavioral properties of these “super bugs”, is strongly influenced by the local hydrodynamics over the microcolonies. Despite the common use of agitated well plates in...
This work presents a numerical simulation of the flow inside agitated well plates commonly used to study bacterial biofilms. The time-varying wall shear stresses are deduced from the calculated velocity field and validated experimentally. The results elucidate aspects of temporal and spatial distribution of the shear stresses acting on biofilm structures grown within these plates. It is shown that...
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