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In an attempt to delineate the capacity of aluminum to promote pro-oxidant events in the central nervous system, levels of nitricoxide synthase (NOS) have been determined in the cerebellum of rats exposed to an aluminum salt, either alone or in combination with an iron compound. Relatively acute treatment with aluminum over a three-day period, increased cerebellar levels of NOS. Parallel results were...
AbstractLevels of glutathione and activity of glutamine synthetase were assayed in organs of rats following inhalation of a heterogeneous solvent mixture containing both aliphatic and aromatic hydrocarbons. This mixture was administered for 3 weeks (6h daily) at two levels in the inhaled air (400 and 800ppm) to young adult (5-month-old) and aged (14-month-old) rats. Depression of levels of glutamine...
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