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In a step-up approach of DMARD treatment of RA a fast response and an early DMARD switch in the case of non-response is important. Therefore, we performed an open trial in which we compared an 8-week and a 16-week observation period during treatment of RA with MTX or LEF, both given in intensified starting doses and accompanied by moderate dose prednisone. MTX and LEF naïve patients with RA (mean...
Das Gehirn reguliert das Energiegleichgewicht des Körpers, indem es Signale aus der Körperperipherie integriert und verarbeitet. Damit gelingt es dem gesunden Organismus, das Körpergewicht durch die verschiedenen Lebensphasen konstant zu halten. Periphere Signale werden von Pankreas, Fettgewebe und dem Verdauungstrakt ausgesandt und beeinflussen durch ihre Wirkung im Gehirn die Nahrungsaufnahme bzw...
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