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The ubiquitination of a protein may promote proteasomal degradation, protein–protein interactions, lysosomal degradation or intracellular trafficking. Transcription factors are targets for ubiquitination by E3-ligase proteins, which results in the regulation in their function. The degradation of transcription factors enables the rapid regulation of gene expression by the ubiquitin–proteasome system...
Immune responses wane during aging, posing challenges to the potential effectiveness of cancer immunotherapies. We previously demonstrated that in the context of a promising immunotherapeutic, OX40 agonist (αOX40), older animals exhibited impaired anti-tumor immune responses and diminished CD4 T cell effector differentiation. In this study, we hypothesized that tumor immune responses could be maintained...
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