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Aims/hypothesis This study evaluated the hypothesis that peroxisome proliferator-activated receptor-γ (PPARγ) agonists, including thiazolidinediones (TZDs) and the rexinoid LG100268 (LG), directly affect human vascular cell function (proliferation, cell cycle, protein expression, lactate release) independently of (1) their PPARγ-activating potential and (2) the cells’ vascular origin. Methods Human...
Aims/hypothesis We examined whether thiazolidinediones (TZDs) acutely affect uncoupling protein-3 (UCP-3) expression in skeletal muscle and plasma NEFA in Sprague-Dawley rats. Methods Expression of UCP-3 mRNA in hindlimb muscles and plasma NEFA were measured after a single intraperitoneal injection of TZDs in healthy male rats. Results Independent of which TZD was injected (50 µmol/kg), UCP-3...
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