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Development of a dysregulated immune response discriminates sepsis from uncomplicated infection. Currently used biomarkers fail to describe simultaneously occurring pro- and anti-inflammatory responses potentially amenable to therapy.Marker candidates were screened by microarray and, after transfer to a platform allowing point-of-care testing, validated in a confirmation set of 246 medical and surgical...
Septic syndroms and the associated perturbation of immune homeo — stasis represent a major health problem in intensive care settings. Aim of our development is a diagnostic tool for monitoring the post-operative host response to assess the risk of early infectious complications. The diagnostic application of an established RNA-biomarker panel from whole blood for septic patients, measured on a qPCR...
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