Search results for: ShuJuan Lai

Items from 1 to 7 out of 7 results

article

Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision

Patrick Mun Yew Chan, Niketa Chotai, Eileen Shujuan Lai, Pei Yi Sin, more

The Breast > 2018 > 37 > C > 13-17

Borderline risk lesions such as flat epithelial atypia (FEA) are increasingly being diagnosed on biopsy. The need for surgery is being debated. In this study, we determined the frequency of histological upgrade following a diagnosis of FEA on biopsy and evaluated potential predictive factors.Retrospective review was done of 194 women who underwent biopsy of indeterminate lesions (total 195 lesions)...

article

Ultra-precise detection of mutations by droplet-based amplification of circularized DNA

Kaile Wang, Qin Ma, Lan Jiang, Shujuan Lai, more

BMC Genomics > 2016 > 17 > 1 > 1-12

Background NGS (next generation sequencing) has been widely used in studies of biological processes, ranging from microbial evolution to cancer genomics. However, the error rate of NGS (0.1 % ~ 1 %) is still remaining a great challenge for comprehensively investigating the low frequency variations, and the current solution methods have suffered severe amplification bias or low efficiency. Results...

article

Erratum to: ‘Ultra-precise detection of mutations by droplet-based amplification of circularized DNA’

Kaile Wang, Qin Ma, Lan Jiang, Shujuan Lai, more

BMC Genomics > 2016 > 17 > 1 > 1-1

article

An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

Qiyan Wang, Jian Bai, Amir Abliz, Ying Liu, more

Genomics, Proteomics & Bioinformatics > 2015 > 13 > 4 > 258-270

Esophageal squamous cell carcinoma (ESCC) has a high mortality rate. To determine the molecular basis of ESCC development, this study sought to identify characteristic genome-wide alterations in ESCC, including exonic mutations and structural alterations. The clinical implications of these genetic alterations were also analyzed. Exome sequencing and verification were performed for nine pairs of ESCC...

article

Development of a two-stage feeding strategy based on the kind and level of feeding nutrients for improving fed-batch production of l-threonine by Escherichia coli

Shuwen Liu, Yong Liang, Qian Liu, Tongtong Tao, more

Applied Microbiology and Biotechnology > 2013 > 97 > 2 > 573-583

Fed-batch fermentation is the predominant method for industrial production of amino acids. In this study, we comprehensively investigated the effects of four kinds of feeding nutrients and developed an accurate optimization strategy for fed-batch production of l-threonine. The production of l-threonine was severely inhibited when cell growth ceased in the bath culture. Similarly, l-threonine production...

article

Genetic and biochemical characterization of Corynebacterium glutamicum ATP phosphoribosyltransferase and its three mutants resistant to feedback inhibition by histidine

Yun Zhang, Xiuling Shang, Aihua Deng, Xin Chai, more

Biochimie > 2012 > 94 > 3 > 829-838

ATP phosphoribosyltransferase (ATP-PRT) catalyzes the condensation of ATP and PRPP at the first step of histidine biosynthesis and is regulated by a feedback inhibition from product histidine. Here, we report the genetic and biochemical characterization of such an enzyme, HisG _Cg , from Corynebacterium glutamicum, including site-directed mutagenesis of the histidine-binding site for the first...

article

Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production

ShuJuan Lai, Yun Zhang, ShuWen Liu, Yong Liang, more

Science China Life Sciences > 2012 > 55 > 4 > 283-290

l-Serine plays a critical role as a building block for cell growth, and thus it is difficult to achieve the direct fermentation of l-serine from glucose. In this study, Corynebacterium glutamicum ATCC 13032 was engineered de novo by blocking and attenuating the conversion of l-serine to pyruvate and glycine, releasing the feedback inhibition by l-serine to 3-phosphoglycerate dehydrogenase (PGDH),...

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Search results for: ShuJuan Lai

Majority of flat epithelial atypia diagnosed on biopsy do not require surgical excision

Ultra-precise detection of mutations by droplet-based amplification of circularized DNA

Erratum to: ‘Ultra-precise detection of mutations by droplet-based amplification of circularized DNA’

An Old Story Retold: Loss of G1 Control Defines A Distinct Genomic Subtype of Esophageal Squamous Cell Carcinoma

Development of a two-stage feeding strategy based on the kind and level of feeding nutrients for improving fed-batch production of l-threonine by Escherichia coli

Genetic and biochemical characterization of Corynebacterium glutamicum ATP phosphoribosyltransferase and its three mutants resistant to feedback inhibition by histidine

Metabolic engineering and flux analysis of Corynebacterium glutamicum for L-serine production

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