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Epstein-Barr virus (EBV) is a human herpesvirus that persistently infects its host for a lifetime through a strategy of growth transforming resting B-cells into continuously proliferating lymphoblastoid cell lines (LCLs) while maintaining itself as an incomplete or “latent” virus in the infected cell nucleus. Immune surveillance is critical to maintaining this symbiosis as perturbations to T-cell...
Summary Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and is associated with malignant B lymphocyte proliferation in AIDS patients, patients undergoing immune suppression for organ transplantation, and SCID mice. In vitro, EBV transformed, latently infected lymphoblastoid B cell lines (LCLs) contain EBV episomes and express nine virus encoded proteins. Six are nuclear proteins...
Summary.Epstein-Barr virus (EBV) causes infectious mononucleosis in adolescents and is associated with malignant B lymphocyte proliferation in AIDS patients, patients undergoing immune suppression for organ transplantation, and SCID mice. In vitro, EBV transformed, latently infected lymphoblastoid B cell lines (LCLs) contain EBV episomes and express nine virus encoded proteins. Six are nuclear proteins...
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