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Modern chemotherapy protocols have improved the prognosis for acute lymphoblastic leukaemia (ALL), one of the most common paediatric malignancies, but their high-dose corticosteroids lead to osteonecrosis in up to 9% of ALL patients. A 13.5-year-old female patient developed massive osteonecrosis of the right knee after successful ALL treatment. She presented at the age of 17.5years as a candidate...
Aufgrund multimodaler Therapieoptionen sind die Lebenserwartung und damit auch die Inzidenz von Knochenmetastasen bei Karzinompatienten in den letzten Jahrzehnten deutlich angestiegen. Die operative Therapie von Skelettmetastasen der Extremitäten ist heute die häufigste onkologische Operation in der orthopädischen Chirurgie. Ziel dieser Studie ist die Evaluierung und Gegenüberstellung der verschiedenen...
Breast cancer is the most frequently diagnosed cancer among women in western countries and bone metastases of breast cancer cause significant morbidity. G proteins are important components of a multitude of transmembrane receptors and are involved in the regulation of intracellular signaling pathways such as parathormone receptors 1 and 2 (PTH1 and 2), extracellular calcium-sensing receptor, the calcitonin...
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