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Neutropenic states are most often a function of haematopoietic failure secondary to myelophthisic disease or cytotoxic therapy for malignant and nonmalignant conditions. Patients so affected are susceptible to a rather wide spectrum of potentially life-threatening infections due to pathogens (bacterial fungal and viral) with a risk inversely proportional to the severity and duration of neutropenia...
The empirical treatment of febrile neutropenic patients with suspected infections is one of the true success stories in the supportive care of patients with hematological malignancies. The essence of the febrile neutropenia paradigm is the shift of focus from microbial pathogens to the immune deficiencies of the host: immune deficiencies intrinsic to the underlying malignancies themselves and to the...
The practice of hematopoietic stem cell transplantation (HSCT) has undergone many changes that affect the likelihood that a given patient would develop an invasive fungal infection (IFI). The risks for IFI and the types of IFI that may occur are not continuous over the time course after transplantation. IFIs vary with the events that occur during the pre-engraftment neutropenic period, the early post-engraftment...
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