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A balance needs to be struck between facilitating compassionate access to innovative treatments for those in desperate need, and the duty to protect such vulnerable individuals from the harms of untested/unlicensed treatments. We introduced a principle‐based framework (2009) to evaluate such requests and describe its application in the context of recently evolved UK, US and European regulatory processes...
Opinion statement Shock in children is a cause of significant morbidity and mortality. Worldwide, most children dying from shock do not have the opportunity to benefit from advanced critical care support and we recommend to readers the World Health Organization ETAT guidelines [1]. For children treated in the intensive care environment, standard cardiovascular measures such as heart rate, pulse volume,...
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