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Intrastriatal injection (16μg) of the neurotoxic dopaminergic agent 6-hydroxydopamine (6-OHDA) in ovariectomized rats caused important reductions in striatal dopamine (DA) and serotonin (5-HT) levels and an increase in GABA content. Treatment of ovariectomized rats with estradiol (5mg 17-β-estradiol administered by a subcutaneous cannula) before 6-OHDA injection maintained the control levels of these...
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