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Intrastriatal injection (16μg) of the neurotoxic dopaminergic agent 6-hydroxydopamine (6-OHDA) in ovariectomized rats caused important reductions in striatal dopamine (DA) and serotonin (5-HT) levels and an increase in GABA content. Treatment of ovariectomized rats with estradiol (5mg 17-β-estradiol administered by a subcutaneous cannula) before 6-OHDA injection maintained the control levels of these neurotransmitters. The administration of estradiol after 6-OHDA injection did not lead to their recovery. These findings suggest that estradiol acts as a neuroprotectant—but not as a neuroreparatory agent—and that it might be able to attenuate striatal dopaminergic neuron degeneration caused by neurotoxic agents.