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Shear shock waves can be generated spontaneously deep within the brain during a traumatic injury. This recently observed behavior could be a primary mechanism for the generation of traumatic brain injuries. However, shear shock wave physics and its numerical modeling are relatively unstudied. Existing numerical solvers used in biomechanics are not designed for the extremely large Mach numbers (greater...
Ultrasound contrast enhanced super resolution imaging has recently attracted extensive attention due to its extraordinary resolution. Vessels that were detected in small animals with ultrafast plane wave imaging sequences were about ten fold smaller than the resolution predicted by a the classical diffraction limit. However the imaging depth in small animals is shallow. To translate this technology...
For the past 50 years head injury biomechanics has been guided by measurements of accelerometers attached to the skull. These measurements provide a partial and indirect estimate of brain motion because the internal deformation of the brain is far more complex than the rigid motion of the skull. In this context, brain tissue behaves nonlinearly under conditions that are generally met by injurious...
Ultrasound contrast enhanced super resolution (CESR) imaging, or ultrasound localization microscopy, has recently attracted extensive attention due to its ability to image microvessels at resolutions much smaller than the ultrasound diffraction limit, with the aid of injected microbubble contrast agents. However, to our knowledge, only shallow in vivo images have been presented. This is largely due...
Nonlinear shear waves have a cubic nonlinearity which generates a unique odd harmonic signature. This behavior was first observed in a homogeneous gelatin phantom with ultrafast plane wave compounding ultrasound imaging and correlation-based tracking algorithm that determines particle motion. However, in heterogeneous tissue, like brain, clutter degrades motion tracking and destroys the weak odd harmonics...
Head injury biomechanics has been guided by measurements of accelerometers attached to the skull, which provides a partial and indirect estimate of brain motion because the internal deformation of the brain is far more complex than the rigid motion of the skull. Attempts to measure the in situ nonlinear brain mechanics with imaging methods (MRI, CT) have lacked the penetration, frame rate, or motion...
Linearly polarized nonlinear shear waves have a cubic nonlinearity which generates shear shock waves. This behavior has been only observed in a homogeneous gelatin phantom with ultrafast plane wave ultrasound imaging and a correlation-based tracking algorithm to determine particle motion. However, in heterogeneous soft tissue, such as brain, clutter degrades motion tracking. We propose a high frame-rate...
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