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Diffusion tensor imaging (DTI) and diffusion kurtosis imaging (DKI) have been previously used to explore white matter related to human immunodeficiency virus (HIV) infection. While DTI and DKI suffer from low specificity, the Combined Hindered and Restricted Model of Diffusion (CHARMED) provides additional microstructural specificity. We used these three models to evaluate microstructural differences...
Background
In patients with relapsed/refractory acute myeloid leukaemia (R/R AML) who received salvage chemotherapy, limited and not updated studies explored the incidence of invasive aspergillosis (IA) and the role of antifungal prophylaxis (AP). The aims of this multicentre retrospective ‘SEIFEM 2016‐B’ study were as follows: (1) to evaluate the current rate and the outcome of proven/probable IA...
Brain tumors therapy is limited by the Blood-Tumor Barrier (BTB) and Blood-Brain Barrier (BBB), still intact in the infiltrative areas. Low intensity Focused Ultrasound (FUS) in conjunction with microbubbles is the only method allowing the local disruption of the BTB/BBB [Hynynen et al. 2001, Zhao et al. 2015]. Proper study of the influence of acoustic scanning parameters (duty cycle, number of focal...
Low intensity Focused Ultrasound (FUS) combined with microbubbles open locally and not invasively the Blood-Brain Barrier (BBB) allowing passage of nanoparticles into the brain [Hynynen et al. 2001]. However, since the quantity of particles that can be delivered with this technique depends on tissue properties, on particle properties as well as on acoustic parameters, so far a model fully predicting...
We present here a new method to study the diffusion process of Gadolinium-based MRI Contrast Agents within the brain extracellular space after ultrasound-induced Blood-Brain Barrier permeabilization. Four compounds were tested (MultiHance, Gadovist, Dotarem and AGuIX). By estimating the Free Diffusion Coefficients from in vitro studies, and the Apparent Diffusion Coefficients from in vivo experiments,...
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