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The primary aim of this work was to develop and study the potential of Capacitive Micro-machined Ultrasound Transducers (CMUTs) for dual-mode ultrasound therapy and imaging. This was investigated in the context of Ultrasound-guided High Intensity Focused Ultrasound (USgHIFU) designed for endocavitary HIFU tissue ablation of the prostate gland. The hypothesis is that this CMUT design could offer potential...
Even though the CMUT technology is currently experiencing an exciting era in the field of ultrasonic imaging, few studies have assessed the real interest of this technology for therapeutic purposes compared to the state-of-the-art technology. Moreover, CMUT transducers could benefit from their low mechanical losses to produce long burst emission without the need of a bulky external cooling device...
The following study is focused on the CMUT intrinsic efficiency for therapeutic purposes. The simulation work is based on electromechanical equivalent circuit analysis and is verified thanks to impedance measurements and pressure field scanning. The good agreement between the overall experiences provides useful understanding on the CMUT behavior and optimization guidelines for therapy-specific CMUT...
The purpose of this work was to investigate the ability of bubbles entrapped within echogenic liposomes (ELIP) to serve as foci for cavitational events that would cause leakage in neighboring non-echogenic liposomes (NELIP). Previous studies have shown that entrapping bubbles into liposomes increases ultrasound-mediated leakage of hydrophilic components at ultrasound settings known to induce inertial...
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