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Targeted ultrasound contrast agents, comprising shell stabilized gas filled microbubbles (MBs), can be used to detect molecular markers of disease present on the vascular endothelium. Current MB imaging techniques exploit the nonlinear echo response of microbubbles to provide signal contrast with respect to adjacent tissue signal. However, these methods are hampered by false positive artifacts arising...
Microbubbles (MBs) are capable of binding specifically to molecular markers on the vascular endothelium to enable sensitive detection of early stage disease. Traditional microbubble imaging techniques rely on the nonlinearity of microbubble signal to differentiate it from surrounding tissue. However, the presence of harmonic energy among echogenic tissue interfaces can limit the effectiveness of these...
Pipe (vessel) phantoms mimicking human tissue and blood flow are widely used for cardiovascular related research in medical ultrasound. Pipe phantom studies require the development of materials and liquids that match the acoustic properties of soft tissue, blood vessel wall, and blood. Over recent years, pipe phantoms have been developed to mimic the molecular properties of the simulated blood vessels...
Targeted microbubbles are currently used as ultrasound contrast agents in pre-clinical studies to visualize disease markers present on the blood vessel endothelium. Rapid clinical translation of targeted microbubble imaging requires a minimization of the diagnostically effective microbubble dose. In this study, we demonstrate an imaging method that improves signal-to-noise ratio (SNR) for microbubble...
Nonlinear echo signals from microbubbles are commonly isolated and visualized using techniques such as pulse inversion (PI) or contrast pulse sequences (CPS). Although these methods function by suppressing the linear signal component, they are still susceptible to detection of a false-positive nonlinear signal arising from strong tissue interfaces. In this study, acoustic radiation force (ARF) was...
Ultrasound-based molecular imaging has been implemented in pre-clinical studies of cancer and cardiovascular diseases. Unfortunately, existing methods face substantial challenges in large blood vessel environments. We hypothesized that a clinically translatable method, the modulated Acoustic Radiation Force (ARF)-based imaging, is capable of rapid detection of inflammation in the abdominal aorta of...
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