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Lipid-stabilized microbubbles are used in various clinical ultrasound (US) applications such as diagnostics imaging and therapeutics. The characteristics of the microbubbles such as size, shell material, and US frequency dictate the acoustic response of these microbubbles. Therefore, monodispersed microbubbles with the length-scale (1–7 μm in diameter) relevant to the biomedical ultrasound applications...
We develop a new microfluidic technique to generate lipid-stabilized microbubbles of 1–7 μm diameter. We shrink microbubbles that are initially O(100) μm in diameter by using a vacuum system. We use a polydimethylsiloxane (PDMS) microfluidic device to generate microbubbles in a conventional flow focusing orifice. The bubbles pass through a serpentine channel while under vacuum pressure, and shrink...
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