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Recent studies indicate that progesterone (PROG) protects against animal brain injury, including ischemic stroke, in various animal models. However, there are insufficient studies about PROG in other various groups such as ovariectomized females and aged animals. This study was designed to examine the efficacy of PROG on infarct volume, brain water content and functional outcome after cerebral ischemia...
Objective and design We evaluated the inhibitory effects of progesterone (PROG) on inflammatory response and its influence on the structure of blood–brain barrier in a permanent model of stroke. Material One hundred and twenty adult male Sprague-Dawley rats were used in this study. Treatments PROG was dissolved in 22.5% 2-hydroxypropyl-bcyclodextrin and given in a dose of 15 mg/kg by intraperitoneal...
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