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The genome of Helicobacter pylori is rich in restriction–modification (RM) systems. Approximately 4% of the genome codes for components of RM systems. hpyAVIBM, which codes for a phase‐variable C5 cytosine methyltransferase (MTase) from H. pylori, lacks a cognate restriction enzyme. Over‐expression of M.HpyAVIB in Escherichia coli enhances the rate of mutations. However, when the catalytically inactive...
Genomic sequences of Helicobacter pylori strains 26695, J99, HPAGI and G27 have revealed an abundance of restriction and modification genes. hp0050, which encodes an N6 adenine DNA methyltransferase, was cloned, overexpressed and purified to near homogeneity. It recognizes the sequence 5′‐GRRG‐3′ (where R is A or G) and, most intriguingly, methylates both adenines when R is A (5′‐GAAG‐3′). Kinetic...
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