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In this paper, we conducted to assembly of microstructures for in vitro 3D cellular structures using self-assembly of magnetized hydrogels. The biocompatible hydrogel microstructures are fabricated by electrodeposition method and ferrite particles are coated on the structures with poly-L-lysine. The microstructures are magnetized by applying 3 T magnetic field, and assembled by the magnetic force...
Fabricated vessel-mimetic microtubes are essential for delivering sufficient nutrient to engineered composite tissues. In this paper, vascular-like microtubes are engineered by automated assembly of donut-shaped micromodules that embed fibroblast cells. A microrobotic system is set up with dual manipulators of 30-nm positioning resolution under an optical microscope. The system assembles the micromodules...
In this study, we describe a novel method of fabricating shape-controlled calcium alginate gel microcapsules. Alginate-poly-L-lysine (PLL) hydrogel microcapsules with predefined shapes were constructed based on electrodeposition method. Firstly, electrolysis of water in alginate solutions with calcium carbonate particles induced alginate gelation on micro-patterned electrode to form 2D gel structures...
The fabrication of vessel-mimetic microchannel provides critical access to enable sufficient nutrient delivery for engineered composite tissues. This paper presents a novel method to engineer vascular-like microchannel by automated assembly of donut-shaped micromodules embedding fibroblast cells. A railed microrobotic system is set up with multi manipulators of 30 nm positioning resolution under an...
Assembly of a micro-tube with small diameter attracts great interest due to its promising contribution on vascular network to deliver oxygen and nutrition in thick biological substitutes. This paper presents a dexterous robotic system with three manipulators to reconstruct the interested micro-tube based on the interaction between bubbles and 2D hydrogel micro-units. Each manipulator has 3 degrees...
Robotic nanomanipulation has achieved a wide range of applications on biomedicine and facilitated a revolutionary breakthrough for it. This paper presents a dexterous nanomanipulation system with three robots coordination for the reconstruction of three-dimensional (3D) artificial microstructure. It is set up with two main components. One is the nanomanipulator with 4 degrees of freedom (DOFs) and...
A novel rail-guided dextrous stick coordination manipulation (DeSCom) system was proposed for the assembly of cell-laden three-dimensional (3D) constructs. The coordination control between three dextrous sticks was realized based on the vision feedback and the manipulation resolution was around 30 nm. It was set up with hybrid motors to ensure the large operation range and operation precision. The...
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