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The healthy human nervous system accurately and robustly controls movements despite nonlinear dynamics, noise, and delays. After a stroke, motor ability frequently becomes impaired. To provide insight into the relative impact of specific sensorimotor deficits on motor performance, we modeled neural control of reaching with the human upper limb as a near-optimally feedback-controlled two-degree-of-freedom...
Stroke is the leading cause of adult disability. Many robots have been developed to administer movement therapies or provide physical assistance to stroke survivors suffering from movement deficits. One effective approach has been to support the weight of the arm, offloading shoulder abductor muscles that have become coupled to elbow muscles. However, patients have limited access to such robots due...
Although it is possible to produce the same movement using an infinite number of different muscle activation patterns owing to musculoskeletal redundancy, the degree to which observed variations in muscle activity can deviate from optimal solutions computed from biomechanical models is not known. Here, we examined the range of biomechanically permitted activation levels in individual muscles during...
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