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Immunophenotyping is widely used to characterize cell populations in basic research and to diagnose diseases from surface biomarkers in the clinic. This process usually requires complex instruments such as flow cytometers or fluorescence microscopes, which are typically housed in centralized laboratories. Microfluidics are combined with an integrated electrical sensor network to create an antibody...
Profiling cell surface markers is indispensable in basic research and clinical diagnostics. In contrast to conventional methods that rely on fluorescent immunolabeling of cells, in article number 1904732, A. Fatih Sarioglu and co‐workers introduce an electronic assay that can perform combinatorial immunophenotyping of cell populations on a disposable microfluidic device with no labels.
Membrane antigen expression analysis of a cell population is routinely needed in clinical applications and basic biology research. In this work, we introduce a microfluidic device that aims to electronically profile the surface antigen density in a given cell population as a low-cost alternative to fluorescent-activated cell sorter. By coupling magnetophoretic cell sorting with an array of code-multiplexed...
Microfluidic Coded Orthogonal Detection by Electrical Sensing (Microfluidic CODES) is a technology that can be used to code-multiplex a large number of electrical sensors on a microfluidic device, so that the spatiotemporal information from suspended particles on the device can be obtained from a single electrical waveform. In this paper, we focus on the scaling of the Microfluidic CODES technology...
Spatial separation of suspended particles based on contrast in their physical or chemical properties forms the basis of various biological assays performed on lab-on-a-chip devices. To electronically acquire this information, we have recently introduced a microfluidic sensing platform, called Microfluidic CODES, which combines the resistive pulse sensing with the code division multiple access in multiplexing...
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