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Drug development commonly studies an adult population first and then the pediatric population. The knowledge from the adult population is taken advantage of for the design of the pediatric trials. Adjusted drug doses for these are often derived from adult pharmacokinetic (PK) models which are extrapolated to patients with smaller body size. This extrapolation is based on scaling physiologic model...
The emergence of the Industrial Internet results in an increasing number of complicated temporal interdependencies between automation systems and the processes to be controlled. There is a need for verification methods that scale better than formal verification methods and which are more exact than testing. Simulation-based runtime verification is proposed as such a method, and an application of Metric...
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