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This paper explores a combined global and local identification approach for linear parameter-varying systems. Ideally, the combined approach retains advantages of its two extremes - global and local - with the possibility to emphasize one or the other. Practically, it is prone to overfitting. This paper proposes a remedy based on the ℓ2,1-norm regularization, describes its implementation within the...
Three novel pyrimidinylhydrazones substituted at either the aromatic moiety or at the imine carbon atom were synthesized and characterized by standard analytical methods. All compounds were found to be toxic in the micro- to submicromolar range against a diverse panel of cancer cell lines including multidrug resistant (MDR) derivatives expressing P-glycoprotein (Pgp). UV–visible spectrophotometry...
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