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Background Epigenetics of schizophrenia provides important information on how the environmental factors affect the genetic architecture of the disease. DNA methylation plays a pivotal role in etiology for schizophrenia. Previous studies have focused mostly on the discovery of schizophrenia-associated SNPs or genetic variants. As postmortem brain samples became available, more and more recent studies...
Parkinson's disease is a chronic degenerative brain disease involving decreased level of dopamine generation and degeneration of substantia nigra. Online biological databases such as PDGene 2012 & 2014, ParkDB and NCBI GEO are built for revealing the potential mechanism of Parkinson's disease. The genetic expression data of microarray from brain tissue of patients with Parkinson's disease...
Mitochondrial dysfunction manifests common central nervous system disorders such as seizures, dementia, ataxia, mitochondrial encephalomyopathy (such as MELARS). Methylation profiles of mitochondrial genes in schizophrenia may help to explain the phenotype of schizophrenic symptoms such as anhedonia, weakness, fatigue and negative symptoms. The dysfunction of mitochondria has been suggested to be...
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