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Detection of ultrasound contrast agents (UCAs) based on their nonlinear characteristics are popular for imaging blood perfusion. For microcirculation imaging, a higher frequency system (>10 MHz) is required to obtain higher spatial resolution. However, high-frequency nonlinear techniques usually suffer from insufficient signal-to-noise ratio (SNR) due to the intense attenuation and the limited...
Stimulating high-frequency nonlinear oscillations of ultrasound contrast agents is helpful to distinguish microbubbles from background tissues. Nevertheless, inefficiency of such oscillations from most commercially available contrast agents and intense attenuation of the resultant high-frequency harmonics limit microbubble detection with high-frequency ultrasound. To avoid this high-frequency nature,...
Characterization of ultrasonic contrast agents (UCAs) destruction provides important information for the design of contrast-assisted perfusion imaging. In this paper, we proposed an acoustical method to demonstrate the relationship between different acoustic exposure conditions and the degree of UCAs destruction. The method also provides a simple and convenient way to determine the bubble destruction...
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