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The positioning and manipulation of large numbers of reagents in small aliquots are paramount to many fields in chemistry and the life sciences, such as combinatorial screening, enzyme activity assays, and point‐of‐care testing. Here, a capillary microfluidic architecture based on self‐coalescence modules capable of storing thousands of dried reagent spots per square centimeter is reported, which...
Microfluidic probes are an emerging tool used in a wide range of applications including surface biopatterning, immunohistology, and cell migration studies. They control flow above a surface by simultaneously injecting and aspirating fluids from a pen-like structure positioned a few tens of microns above a surface. Rather than confining flows inside microchannels they rely on recirculating flow patterns...
We provide analysis of different regimes of diffusion and laminar flow convection combined with bimolecular surface reactions relevant to biochemical assays performed in microfluidic devices. Analytic solutions for concentration fields are compared to predictions from two-dimensional finite element simulations for the various operation regimes. The analytic and numerical results extend the transport...
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