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Bacterial lipoproteins are characterized by the presence of a conserved N‐terminal lipid‐modified cysteine residue that allows the hydrophilic protein to anchor onto bacterial cell membranes. These proteins play important roles in a wide variety of bacterial physiological processes, including virulence, and induce innate immune reactions by functioning as ligands of the mammalian Toll‐like receptor...
We previously reported that Staphylococcus aureus avoids killing within macrophages by exploiting the action of Toll‐like receptor 2 (TLR2), which leads to the c‐Jun N‐terminal kinase (JNK)‐mediated inhibition of superoxide production. To search for bacterial components responsible for this event, a series of S. aureus mutants, in which the synthesis of the cell wall was interrupted, were screened...
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