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Background Scleroderma Renal Crisis (SRC) is associated with significant morbidity and mortality. While prednisone is strongly associated with SRC, there are no previous large cohort studies that have evaluated ace inhibitor (ACEi) calcium channel blocker (CCB), angiotensin receptor blocker (ARB), endothelin receptor blocker (ERB), non-steroidal anti-inflammatory drug (NSAID), fluticasone, or mycophenolate...
Statistically extreme events, that is to say, the events which have L-shaped probability distribution function (PDF, or in other words L-statistics) and, in particular, the rogue wave (RW) events, constitute a special family of natural phenomena. Curiously, this kind of events is more common than it is believed. It was observed that the behavior of the systems which obey L-shaped statistics is clustered...
We introduce an open-access online database containing high density datasets from various nonlinear laser systems as a resource for facilitating comparisons between theory and experiment, and for answering new research questions. The database is also useful in data science and machine learning.
Nanoparticles are rapidly becoming ubiquitous in modern technology and so there is an emerging need to characterise single nanoparticles rapidly and accurately. In the current technological paradigm, non-optical techniques such as electron microscopy (EM) and atomic-force microscopy (AFM) are favored for this role. Nano-characterization using optical microscopy though has several advantages; it can...
There is an emerging interest in natural silks as an optical material due to their attractive optical and mechanical properties, potential to engineer their properties by modifying their protein structure and relative ease with which natural silk can be obtained. There a need to develop accessible new optical characterisation techniques that can be applied to these challenging samples. Here, we present...
Optical surface profilers are useful metrological instruments, however their application to nanometrology is hindered because ray-optic approximations are included in the physical model that relates measurand (irradiance profiles) to the height profile of the object surface [1-2]. Using optical surface profilometry for nanometrology is an attractive prospect because they are compatible with conventional...
Refractive-index measurements of spider silks using image-contrast immersion methods are presented, with a precision twenty times greater than has previously been attained. Dispersion and birefringence measurements of the spider silks are also realised.
The use of a scanned femtosecond laser focus to create optical waveguide devices is an established and powerful technique [1] with applications in sensing and quantum information [2]. Using a sub-surface focussed femtosecond laser, a dielectric material can be modified at a highly localised point without surrounding material modification. By controlling the laser-photonic material interactions and...
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