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The purpose of this study is to give researchers improved access to important electrophysiological quantities, such as ion-channel gating variables, that are difficult or impossible to measure during in vitro experiments, yet are thought to be critical to the formation of dangerous arrhythmias. To help fulfill this goal, we examined the feasibility of inferring these types of quantities from more...
Mathematical models of cardiac action potential (AP) dynamics are useful for studying the formation of dynamically significant patterns such as alternans and conduction block. A closed-loop observer is an augmented version of a mathematical model, in which experimental data are supplied to the model through feedback. In this study, tools for observer analysis were applied to a two-variable Karma model...
Sudden cardiac arrest is a widespread cause of death in the industrialized world. Most cases of sudden cardiac arrest are due to ventricular fibrillation (VF), a lethal cardiac arrhythmia. Electrophysiological abnormalities such as alternans (a beat-to-beat alternation in action potential duration) and conduction block have been suspected to contribute to the onset of VF. This study focuses on the...
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