Search results for: Heinrich Wolf

Items from 1 to 20 out of 31 results

article

Full or intensity‐reduced high‐dose melphalan and single or double autologous stem cell transplant with or without bortezomib consolidation in patients with newly diagnosed multiple myeloma

Christian Straka, Hans Salwender, Stefan Knop, Martin Vogel, more

European Journal of Haematology > 107 > 5 > 529 - 542

Objective A post hoc subgroup analysis of two phase III trials (NCT00416273, NCT00416208) was carried out to investigate the influence of 100/140 and 200 mg/m² melphalan as well as single/double autologous stem cell transplantation (ASCT) on progression‐free survival (PFS). Additionally, the effect of bortezomib consolidation on PFS was analyzed. Methods Following induction therapy and high‐dose...

article

Bortezomib consolidation following autologous transplant in younger and older patients with newly diagnosed multiple myeloma in two phase III trials

Christian Straka, Stefan Knop, Martin Vogel, Jürgen Müller, more

European Journal of Haematology > 103 > 3 > 255 - 267

Objective A post hoc analysis of two phase III trials was carried out to explore the influence of age and treatment factors on the effect of bortezomib consolidation on progression‐free survival (PFS) post autologous stem cell transplantation (ASCT). Methods Patients with newly diagnosed multiple myeloma were assigned to one of two trials (ClinicalTrials.gov IDs: NCT00416273, NCT00416208), which...

article

Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma: DSMM XI trial

Hermann Einsele, Monika Engelhardt, Christoph Tapprich, Jürgen Müller, more

British Journal of Haematology > 179 > 4 > 586 - 597

We assessed the safety and efficacy of bortezomib, cyclophosphamide and dexamethasone (VCD) induction therapy in previously untreated multiple myeloma patients. A total of 414 patients received three 21‐day cycles of VCD prior to autologous stem‐cell transplantation (ASCT). Most common grade ≥3 adverse events were leucopenia (31·4%) and thrombocytopenia (6·8%). The overall response rate (ORR) by investigator‐based...

chapter

Correlation limits between capacitively coupled transmission line pulsing (CC-TLP) and CDM for a large chip-on-flex assembly

Johannes Weber, Wolfgang Reinprecht, Horst Gieser, Heinrich Wolf, more

2017 39th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD) > 1 - 7

2017 39th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD)

For the first time this correlation study compares air discharge CDM and contact-mode Capacitively Coupled Transmission Line Pulsing (CC-TLP) for a large chip-on-flex assembly e.g. for the Internet of Things (IOT) applications. Both ground planes overlap only part of the flexible substrate with long traces. Correlation can be established according to impulse energy and multi-zap wear-out effects rather...

chapter

Correlation study of different CDM testers and CC-TLP

Johannes Weber, Karim T. Kaschani, Horst Gieser, Heinrich Wolf, more

2017 39th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD) > 1 - 10

2017 39th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD)

This paper analyzes the correlation between test results of three different CDM testers and corresponding results of Capacitively Coupled Transmission Line Pulsing (CC-TLP). Furthermore, it discusses the significance of the current slew rate as an additional failure threshold and the reasons for a poor reproducibility of CDM failures.

article

Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

Marie von Lilienfeld-Toal, Annemarie Berger, Maximilian Christopeit, Marcus Hentrich, more

European Journal of Cancer > 2016 > 67 > C > 200-212

Community acquired viruses (CRVs) may cause severe disease in cancer patients. Thus, efforts should be made to diagnose CRV rapidly and manage CRV infections accordingly.A panel of 18 clinicians from the Infectious Diseases Working Party of the German Society for Haematology and Medical Oncology have convened to assess the available literature and provide recommendations on the management of CRV infections...

article

High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial

Gerald Illerhaus, Benjamin Kasenda, Gabriele Ihorst, Gerlinde Egerer, more

The Lancet Haematology > 2016 > 3 > 8 > e388-e397

High-dose methotrexate-based chemotherapy is standard for primary CNS lymphoma, but most patients relapse. High-dose chemotherapy with autologous stem cell transplantation (HCT-ASCT) is supposed to overcome the blood–brain barrier and eliminate residual disease in the CNS. We aimed to investigate the safety and efficacy of HCT-ASCT in patients with newly diagnosed primary CNS lymphoma. In this...

article

Dysautonomic polyneuropathy as a variant of chronic inflammatory “demyelinating” polyneuropathy?

Hans-Heinrich Wolf, Malte Erich Kornhuber, Joachim Weis, Andreas Posa

Clinical Autonomic Research > 2016 > 26 > 4 > 303-305

This report describes the clinical course over almost one decade of a male patient presenting with immune-mediated pure autonomic neuropathy resembling a distinct variant of chronic dysimmune polyneuropathies. We suppose autoantibodies directed against epitopes on autonomic axons or neurons causative for the symptoms.

article

Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH)

Iris Appelmann, Stephan Kreher, Stefani Parmentier, Hans-Heinrich Wolf, more

Annals of Hematology > 2016 > 95 > 5 > 707-718

Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPN) comprise a heterogeneous group of chronic hematologic malignancies. The quality of life, morbidity, and mortality of patients with MPN are primarily affected by disease-related symptoms, thromboembolic and hemorrhagic complications, and progression to myelofibrosis and acute leukemia. Major bleeding represents a common and important...

chapter

Using CC-TLP to get a CDM robustness value

Kai Esmark, Reinhold Gaertner, Stefan Seidl, Friedrich zur Nieden, more

2015 37th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD) > 1 - 10

2015 37th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD)

Charged Device Model (CDM) like stress represents the highest ESD risk during handling of single devices. Today air discharge compromises repeatability of CDM tests of products in a package. The paper demonstrates that the repeatable Capacitive Coupled TLP (CC-TLP) reproduces CDM failure signatures at both package and wafer level. Data will be shown to compare the stress failing level and the failure...

chapter

Secondary discharge - A potential risk during system level ESD testing

Heinrich Wolf, Horst Gieser

2015 37th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD) > 1 - 7

2015 37th Electrical Overstress/Electrostatic Discharge Symposium (EOS/ESD)

By means of a floating handheld electronic product this work describes the influence of secondary discharge events during system level ESD testing on the failure threshold of the involved electronic circuit. In order to increase the robustness it was necessary to determine the discharge current target levels by a dedicated test set-up which was also used to verify the success of system modifications...

article

Treatment of invasive fungal infections in cancer patients—updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Sabine Mousset, Dieter Buchheidt, Werner Heinz, Markus Ruhnke, more

Annals of Hematology > 2014 > 93 > 1 > 13-32

The Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO) here presents its updated recommendations for the treatment of documented fungal infections. Invasive fungal infections are a main cause of morbidity and mortality in cancer patients undergoing intensive chemotherapy regimens. In recent years, new antifungal agents have been licensed, and agents already...

chapter

Transmission lines on flexible substrates with minimized dispersion and losses

Heinrich Wolf, Horst Gieser, Linus Maurer

2013 European Microwave Conference > 1419 - 1422

2013 European Microwave Conference (EuMC)

This work describes the characterization of high frequency transmission lines realized on flexible substrates. In order to investigate technology related aspects influencing the performance of the transmission lines the study includes two different technologies. The first one is a commercially available process applying a subtractive layer definition on Polyimide (PI) and Liquid Cristal Polymer (LCP)...

chapter

Transmission lines on flexible substrates with minimized dispersion and losses

Heinrich Wolf, Horst Gieser, Linus Maurer

2013 European Microwave Integrated Circuit Conference > 448 - 451

2013 European Microwave Integrated Circuit Conference (EuMIC)

article

Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples

Mark Reinwald, Birgit Spiess, Werner J. Heinz, Jörg J. Vehreschild, more

European Journal of Haematology > 89 > 2 > 120 - 127

ObjectivesDiagnosing invasive pulmonary aspergillosis (IPA) remains a challenge in patients with hematological malignancies. The clinical significance of testing bronchoalveolar lavage (BAL) samples both with polymerase chain reaction (PCR) and Aspergillus galactomannan ELISA (GM) is unclear, and the BAL cutoff for GM has not been clearly evaluated yet. MethodsUsing a validated nested PCR assay and...

article

Investigating the CDM susceptibility of IC’s at package and wafer level by capacitive coupled TLP

Heinrich Wolf, Horst Gieser, Dirk Walter

Microelectronics Reliability > 2009 > 49 > 12 > 1476-1481

The method of the capacitive coupled transmission line pulsing (CC-TLP) is applied to a product IC at package level and for the first time at wafer level. The investigated product showed a field failure which could be reproduced by the CDM. The application of the CC-TLP to the product at package and wafer level also reproduced the field failure. Furthermore the measured failure currents correlate...

article

Safety and efficacy of a triple antiemetic combination with the NK-1 antagonist aprepitant in highly and moderately emetogenic multiple-day chemotherapy

Karin Jordan, Iris Kinitz, Wieland Voigt, Timo Behlendorf, more

European Journal of Cancer > 2009 > 45 > 7 > 1184-1187

In multiple-day chemotherapy (MDC), the combination of a 5-HT ₃ -antagonist plus dexamethasone is still a standard of care. The role of a NK-1-antagonist remains to be defined.Seventy eight cancer patients undergoing multiple-day chemotherapy of high (HEC) or moderate (MEC) emetic risk received granisetron, dexamethasone plus aprepitant during chemotherapy. After the end of chemotherapy, aprepitant...

chapter

Modeling and measurement of coplanar transmission lines with significant proximity and surface roughness effects

Brian Curran, Ivan Ndip, Christian Werner, Veronika Ruttkowski, more

2009 European Microwave Conference (EuMC) > 890 - 893

2009 39th European Microwave Conference (EuMC)

New technologies have resulted in transmission lines that deviate significantly from the intended rectangular cross-sections. Trapezoidal cross-sections and roughness that penetrates a significant depth into the surface in comparison to the thickness of the conductor can cause a very significant deviation in transmission line parameters from predicted values. Proximity effects further complicate the...

article

Central venous catheter-related infections in hematology and oncology

Hans-Heinrich Wolf, Malte Leithäuser, Georg Maschmeyer, Hans Salwender, more

Annals of Hematology > 2008 > 87 > 11 > 863-876

Catheter-related infections (CRI) cause considerable morbidity in hospitalized patients. The incidence does not seem to be higher in neutropenic patients than in nonneutropenic patients. Gram-positive bacteria (coagulase-negative staphylococci, Staphylococcus aureus) are the pathogens most frequently cultured, followed by Candida species. Positive blood cultures are the cornerstone in the diagnosis...

article

ESD Susceptibility of Submicron Air Gaps

Heinrich Wolf, Horst Gieser, Detlef Bonfert, Markus Hauser

Microelectronics Reliability > 2006 > 46 > 9-11 > 1587-1590

This work describes the investigation of the ESD susceptibility of submicron air gaps which are used e.g. in filter devices. The breakdown behaviour of the air gaps is analyzed in both the HBM (Human Body Model) time domain and the CDM (Charged Device Model) time domain. Transmission Line pulsing (TLP) reproduces the different failure signatures. Furthermore, the failure model itself is explained...

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Search results for: Heinrich Wolf

Full or intensity‐reduced high‐dose melphalan and single or double autologous stem cell transplant with or without bortezomib consolidation in patients with newly diagnosed multiple myeloma

Bortezomib consolidation following autologous transplant in younger and older patients with newly diagnosed multiple myeloma in two phase III trials

Phase II study of bortezomib, cyclophosphamide and dexamethasone as induction therapy in multiple myeloma: DSMM XI trial

Correlation limits between capacitively coupled transmission line pulsing (CC-TLP) and CDM for a large chip-on-flex assembly

Correlation study of different CDM testers and CC-TLP

Community acquired respiratory virus infections in cancer patients—Guideline on diagnosis and management by the Infectious Diseases Working Party of the German Society for haematology and Medical Oncology

High-dose chemotherapy with autologous haemopoietic stem cell transplantation for newly diagnosed primary CNS lymphoma: a prospective, single-arm, phase 2 trial

Dysautonomic polyneuropathy as a variant of chronic inflammatory “demyelinating” polyneuropathy?

Diagnosis, prevention, and management of bleeding episodes in Philadelphia-negative myeloproliferative neoplasms: recommendations by the Hemostasis Working Party of the German Society of Hematology and Medical Oncology (DGHO) and the Society of Thrombosis and Hemostasis Research (GTH)

Using CC-TLP to get a CDM robustness value

Secondary discharge - A potential risk during system level ESD testing

Treatment of invasive fungal infections in cancer patients—updated recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Oncology (DGHO)

Transmission lines on flexible substrates with minimized dispersion and losses

Transmission lines on flexible substrates with minimized dispersion and losses

Diagnosing pulmonary aspergillosis in patients with hematological malignancies: a multicenter prospective evaluation of an Aspergillus PCR assay and a galactomannan ELISA in bronchoalveolar lavage samples

Investigating the CDM susceptibility of IC’s at package and wafer level by capacitive coupled TLP

Safety and efficacy of a triple antiemetic combination with the NK-1 antagonist aprepitant in highly and moderately emetogenic multiple-day chemotherapy

Modeling and measurement of coplanar transmission lines with significant proximity and surface roughness effects

Central venous catheter-related infections in hematology and oncology

ESD Susceptibility of Submicron Air Gaps

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