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We present a novel biophotonic method and imaging modality for estimating and mapping neoplasia-specific functional and structural parameters of the cervical precancerous epithelium. Estimations were based on experimental data obtained from dynamic contrast-enhanced optical imaging of cervix, in vivo. We have developed a pharmacokinetic, in silico, model of the optical tracer's uptake by the epithelium...
We present the first in silico simulation of biomarker uptake kinetics and of the associated dynamic optical signals, measured in vivo in neoplastic epithelial tissue. We introduce a new, non-invasive method for estimating and mapping of both structural and functional, neoplasia-correlated parameters. The method relies on model-based fitting of dynamic optical signals, measured in vivo, and on solving...
We present a method for detecting and studying neoplasia-specific functional and structural features through the combination of in vivo dynamic imaging, in silico modeling and global sensitivity analysis. We particularly present the case of cervical epithelium interacting with acetic acid solution, which is employed as an optical biomarker. The in vivo measured dynamic scattering characteristics are...
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