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Membrane bound Fas ligand (FasL, Apo-1L, CD95L), a member of the tumor necrosis factor family, induces rapid apoptosis in Fas-bearing cells. Human keratinocytes are known to undergo apoptotic cell death under physiologic and pathologic conditions, and have been shown to express Fas. Here we show that FasL is also expressed in human keratinocytes, and have analyzed its expression in vivo and its function...
A novel member of the tumor necrosis factor (TNF) receptor family, designated TRAMP, has been identified. The structural organization of the 393 amino acid long human TRAMP is most homologous to TNF receptor 1. TRAMP is abundantly expressed on thymocytes and lymphocytes. Its extracellular domain is composed of four cysteine-rich domains, and the cytoplasmic region contains a death domain known to...
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