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Alarm systems are vital for the safe operation of almost all large-scale industrial and technical installations, such as chemical plants or power stations. The optimization of alarm systems has great potential to improve the safety of these installations, and also to increase their profitability through the reduction of automated shut-downs and suboptimal operation modes. In this work we present a...
Computer models provide a powerful platform for investigating mechanisms that underlie atrial rhythm disturbances. We have used novel techniques to build a structurally-detailed, image-based model of 3-D atrial anatomy. A volume image of the atria from a normal sheep heart was acquired using serial surface macroscopy, then smoothed and down-sampled to 50 resolution. Atrial surface...
Sheep is an animal model often used for experimental studies into the underlying mechanisms of cardiac arrhythmias. Previous studies have shown that biophysically detailed computer models of the heart provide a powerful alternative to experimental animal models for underpinning such mechanisms. In this study we have developed a family of mathematical models for the electrical action potentials of...
Heterogeneity in the electrical action potential (AP) properties can provide a substrate for atrial arrhythmias, especially at rapid pacing rates. In order to quantify such substrates, we develop a family of detailed AP models for canine atrial cells. An existing model for the canine right atrial (RA) myocyte was modified based on electrophysiological data from dog to create new models for the canine...
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