Search results for: Yi-Ling Hsieh

Items from 1 to 20 out of 27 results

article

Postirradiated carotid blowout syndrome in patients with nasopharyngeal carcinoma: A case–control study

Kun‐Chih Chen, Ting‐Ting Yen, Yi‐Ling Hsieh, Hung‐Chieh Chen, more

BackgroundCarotid blowout syndrome is one of the most devastating complications of nasopharyngeal carcinoma (NPC) therapy. MethodsA retrospective review was conducted from January 2004 to April 2013. Thirty‐one patients with carotid blowout syndrome were enrolled and a case control study was conducted to analyze the risk factors. ResultsWhen a comparison was made between the carotid blowout syndrome...

article

Salt Stability – The Effect of pH_max on Salt to Free Base Conversion

Yi-Ling Hsieh, Jeremy M. Merritt, Weili Yu, Lynne S. Taylor

Pharmaceutical Research > 2015 > 32 > 9 > 3110-3118

Purpose The aim of this study was to investigate how the disproportionation process can be impacted by the properties of the salt, specifically pH_max. Methods Five miconazole salts and four sertraline salts were selected for this study. The extent of conversion was quantified using Raman spectroscopy. A mathematical model was utilized to estimate the theoretical amount of conversion. Results A...

article

Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion

Yi-Ling Hsieh, Lynne S. Taylor

Pharmaceutical Research > 2015 > 32 > 2 > 549-561

Purpose The aim of this study was to investigate how factors such as temperature, relative humidity and particle size impact the extent of disproportionation (salt to free base conversion) in powder blends of miconazole, benzocaine or sertraline mesylate salts mixed with a basic additive. Method Raman spectroscopy was used to quantitate the extent of disproportionation. The data was further analyzed...

article

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Samir Mehndiratta, Yi-Ling Hsieh, Yi-Min Liu, Amber Weiching Wang, more

European Journal of Medicinal Chemistry > 2014 > 85 > Complete > 468-479

A series of 2-methyl-1H-indol-3-ethylsulfamoylphenylacrylamides based on LBH589–PXD101 core have been synthesized and evaluated for their histone deacetylase (HDAC) inhibitory and anti-inflammatory activity. In vitro, compounds 9–12 show 2.6-fold better HDAC inhibition and 3-fold better IL-6 suppression compared to LBH589·HCl (1·HCl). Furthermore, these compounds did not show apparent cell viability...

article

Assessing the Impact of Polymers on the pH‐Induced Precipitation Behavior of Poorly Water Soluble Compounds using Synchrotron Wide Angle X‐Ray Scattering

Yi‐Ling Hsieh, Karl Box, Lynne S. Taylor

Journal of Pharmaceutical Sciences > 103 > 9 > 2724 - 2735

The aim of this study was to investigate the pH‐induced precipitation behavior of four ionizable compounds (papaverine, dipyridamole, glyburide, and warfarin) in the absence and presence of polymers. Polymers selected included nonionic, anionic, and cationic polymers. Precipitates were analyzed immediately after formation using high‐energy radiation wide‐angle X‐ray scattering analysis and polarized...

article

Laryngeal electromyography findings of vocal fold immobility in patients after radiotherapy for nasopharyngeal carcinoma

Yi‐Ling Hsieh, Ming‐Hong Chang, Chen‐Chi Wang

Head & Neck > 36 > 6 > 867 - 872

BackgroundThe clinical features of vocal fold immobility (VFI) after radiotherapy for nasopharyngeal carcinoma (NPC) have seldom been reported. MethodsWe retrospectively reviewed laryngeal electromyography (LEMG) and tumor study findings to elucidate the common clinical features of patients who presented with VFI after radiotherapy for NPC. The LEMG signals obtained from the cricothyroid and thyroarytenoid...

article

Impact of sertraline salt form on the oxidative stability in powder blends

Yi-Ling Hsieh, Weili Yu, Yanqiao Xiang, Weitao Pan, more

International Journal of Pharmaceutics > 2014 > 461 > 1-2 > 322-330

Oxidation of active pharmaceutical ingredients is a common chemical degradation process occurring in solid dosage forms. The aim of this study was to investigate the tendency of various sertraline salts to oxidize in powder blends containing a basic additive. A different extent of conversion of each salt to the free base was observed to occur in the presence of the basic additive, consistent with...

article

Biochip Synthesis and Dynamic Error Recovery for Sample Preparation Using Digital Microfluidics

Yi-Ling Hsieh, Tsung-Yi Ho, Krishnendu Chakrabarty

IEEE Transactions on Computer-Aided Design of Integrated Circuits and... > 2014 > 33 > 2 > 183 - 196

Recent advances in digital microfluidic biochips have led to a promising future for miniaturized laboratories, with the associated advantages of high sensitivity and reconfigurability. Since sample preparation plays an important front-end role in assays and laboratories in biochemical applications, and most of the analysis time is associated with sample collection, transportation, and preparation,...

article

Classification of the Crystallization Behavior of Amorphous Active Pharmaceutical Ingredients in Aqueous Environments

Bernard Eerdenbrugh, Shweta Raina, Yi-Ling Hsieh, Patrick Augustijns, more

Pharmaceutical Research > 2014 > 31 > 4 > 969-982

Purpose To classify the crystallization behavior of amorphous active pharmaceutical ingredients (API) exposed to aqueous environments. Methods A set of approximately 50 chemically and physically diverse active pharmaceutical ingredients (APIs) was selected for this study. Two experimental setups were employed to characterize the crystallization behavior of the amorphous API in an aqueous environment...

chapter

A road-based QoS-aware multipath routing for urban vehicular ad hoc networks

Yi-Ling Hsieh, Kuochen Wang

2012 IEEE Global Communications Conference (GLOBECOM) > 189 - 194

GLOBECOM 2012 - 2012 IEEE Global Communications Conference

Stable and efficient routing plays a key role for the success of VANETs. Road-based routing has been shown well-suited for urban VANETs, and multipath routing provides alternative routes once the current route fails. However, existing multipath routing protocols are node-based, which are not suitable for urban VANETs. In this paper, we propose a road-based QoS-aware multipath routing protocol for...

article

Dynamic overlay multicast for live multimedia streaming in urban VANETs

Yi-Ling Hsieh, Kuochen Wang

Computer Networks > 2012 > 56 > 16 > 3609-3628

Infotainment service has been a foreseeing trend in VANETs (Vehicular Ad Hoc Networks), and multimedia streaming has a high potential in VANET infotainment service. This paper considers the scenario of live multimedia streaming multicast to vehicles of the same group using a dynamic application layer overlay. Due to the willingness for cooperation of non-group nodes, application layer overlay multicast...

chapter

Design methodology for sample preparation on digital microfluidic biochips

Yi-Ling Hsieh, Tsung-Yi Ho, Krishnendu Chakrabarty

2012 IEEE 30th International Conference on Computer Design (ICCD) > 189 - 194

2012 IEEE 30th International Conference on Computer Design (ICCD 2012)

Recent advances in digital microfluidic biochips have led to a promising future for miniaturized laboratories, with the associated advantages of high sensitivity and reconfigurability. As one of the front-end operations on digital microfluidic biochips, sample preparation plays an important role in biochemical assays and applications. For fast and high-throughput biochemical applications, it is critical...

article

A Reagent-Saving Mixing Algorithm for Preparing Multiple-Target Biochemical Samples Using Digital Microfluidics

Yi-Ling Hsieh, Tsung-Yi Ho, Krishnendu Chakrabarty

IEEE Transactions on Computer-Aided Design of Integrated Circuits and... > 2012 > 31 > 11 > 1656 - 1669

Recent advances in digital microfluidics have led to the promise of miniaturized laboratories, with the associated advantages of high sensitivity and less human-induced errors. Front-end operations such as sample preparation play a pivotal role in biochemical laboratories, and in applications in biomedical engineering and life science. For fast and high-throughput biochemical applications, preparing...

article

pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

Yi-Ling Hsieh, Grace A. Ilevbare, Bernard Van Eerdenbrugh, Karl J. Box, more

Pharmaceutical Research > 2012 > 29 > 10 > 2738-2753

Purpose To examine the precipitation and supersaturation behavior of ten weak bases in terms of the relationship between pH-concentration-time profiles and the solid state properties of the precipitated material. Methods Initially the compound was dissolved at low pH, followed by titration with base to induce precipitation. Upon precipitation, small aliquots of acid or base were added to induce...

chapter

On-chip biochemical sample preparation using digital microfluidics

Yi-Ling Hsieh, Tsung-Yi Ho, Krishnendu Chakrabarty

2011 IEEE Biomedical Circuits and Systems Conference (BioCAS) > 297 - 300

2011 IEEE Biomedical Circuits and Systems Conference (BioCAS)

Sample preparation plays a pivotal role in bioassay operations on digital microfluidic biochips (DMFBs). This paper proposes a dilution/mixing method with high utilization of intermediate droplets for preparing biochemical samples of multiple target concentrations on DMFBs. It provides the first solution to the problem of generating samples of multiple target concentrations. Unlike prior work in which...

chapter

A reliable routing scheme based on vehicle moving similarity for VANETs

Min-Hsuan Wei, Kuochen Wang, Yi-Ling Hsieh

TENCON 2011 - 2011 IEEE Region 10 Conference > 426 - 430

TENCON 2011 - 2011 IEEE Region 10 Conference

In this paper, we propose a reliable routing scheme based on vehicle moving similarity (RR-VMS), which focuses on stable rebroadcast nodes selection and route discovery to make inter-vehicle data transmissions more reliable. We select nearby vehicles having similar velocities with the source vehicle as rebroadcast nodes. We call these vehicles having moving similarity with the source vehicle. To reflect...

article

Complex dielectric properties of microcrystalline cellulose, anhydrous lactose, and α‐lactose monohydrate powders using a microwave‐based open‐reflection resonator sensor

Pei‐Fang Sung, Yi‐Ling Hsieh, Kristen Angonese, Don Dunn, more

Journal of Pharmaceutical Sciences > 100 > 7 > 2920 - 2934

The real (ε′) and imaginary (ε″) components of the complex permittivity of anhydrous lactose and microcrystalline cellulose (MCC) under different bulk densities, moisture contents (MCs), and times of hydration (for anhydrous lactose) were measured nondestructively using a microwave resonator sensor operating in the range of 700–800 MHz. Measurements of sensor resonant frequency and conductance allow,...

chapter

Road Layout Adaptive Overlay Multicast for Urban Vehicular Ad Hoc Networks

Yi-Ling Hsieh, Kuochen Wang

2011 IEEE 73rd Vehicular Technology Conference (VTC Spring) > 1 - 5

2011 IEEE Vehicular Technology Conference (VTC 2011-Spring)

Infotainment service is getting popular in vehicular ad hoc networks (VANETs). Through inter-vehicle communication, vehicles can retrieve data from other vehicles, including multimedia data. In this paper, we propose an Overlay Multicast for VANETs (OMV). In OMV, interested vehicles (called group member nodes) join a multicast tree initiated by a vehicle providing multimedia data as the multicast...

chapter

Automated Physical Design of Microchip-Based Capillary Electrophoresis Systems

Yi-Ling Hsieh, Tsung-Yi Ho

2011 24th Internatioal Conference on VLSI Design > 165 - 170

2011 24th International Conference on VLSI Design: concurrently with the 10th International Conference on Embedded Systems Design

Recently, micro fluidic biochips are gaining much attention. Especially microchip-based capillary electrophoresis system is one of the techniques that are developed in the area of separation on a microchip. In this paper, we present an automated physical design methodology for microchip based capillary electrophoresis channel systems. The proposed methodology includes three stages: (1) placement of...

article

Efficient Color-theory-based Dynamic Localization for Mobile Wireless Sensor Networks

Shen-Hai Shee, Tzu-Chien Chang, Kuochen Wang, Yi-Ling Hsieh

Wireless Personal Communications > 2011 > 59 > 2 > 375-396

Location information is critical to mobile wireless sensor networks (WSN) applications. With the help of location information, for example, routing can be performed more efficiently. In this paper, we propose a novel localization approach, Color-theory based Dynamic Localization (CDL), which is based on color theory to exploit localization in mobile WSNs. CDL makes use of the broadcast information,...

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ROUTING (4)
AMORPHOUS (3)
CRYSTALLIZATION (3)
MOBILE WIRELESS SENSOR NETWORK (3)
PEER TO PEER COMPUTING (3)
PROTOCOLS (3)
STREAMING MEDIA (3)
AD HOC NETWORKS (2)
DIGITAL MICROFLUIDICS (2)
DYNAMIC LOCALIZATION (2)
INTERNET (2)
LAYOUT (2)
MULTIMEDIA COMMUNICATION (2)
NASOPHARYNGEAL CARCINOMA (2)
PEER-TO-PEER COMPUTING (2)
PROTEINS (2)
QOS (2)
RADIOTHERAPY (2)
ROUTING PROTOCOLS (2)
SAMPLE PREPARATION (2)
SIMULATION (2)
VEHICLES (2)
WIRELESS SENSOR NETWORKS (2)
ACID BASE REACTION (1)
ACID/BASE (1)
ACTIVE PHARMACEUTICAL INGREDIENT (1)
ANTI-INFLAMMATORY ACTIVITY (1)
APPLICATION LEVEL MULTICAST (1)
ARRAYS (1)
AUTOMATED PHYSICAL DESIGN (1)
AUXILIARY CHANNELS ROUTING (1)
AVERAGE HOP DISTANCE (1)
BIOAVAILABILITY (1)
BUFFERING CAPACITY (1)
CALL SETUP LATENCY (1)
CAROTID BLOWOUT SYNDROME (1)
CHEMICALS (1)
CHEMOTHERAPY (1)
CHORD-BASED P2P SIP SYSTEM (1)
COLOR THEORY (1)
COLOR-THEORY-BASED (1)
CONFERENCES (1)
DATA COMMUNICATION (1)
DELAY (1)
DESIGN METHODOLOGY (1)
DETECTORS (1)
DHT BASED ROUTING ALGORITHM (1)
DISPROPORTIONATION (1)
DISTRIBUTED ALGORITHMS (1)
DISTRIBUTED HASH TABLE (1)
DISTRIBUTED RANGE-FREE LOCALIZATION APPROACH (1)
DRL (1)
DRYING (1)
DYNAMIC OVERLAY MULTICAST (1)
DYNAMIC SEED FLOODING (1)
EDUCATIONAL INSTITUTIONS (1)
ELECTRODES (1)
ELECTROPHORESIS (1)
ENERGY SAVING (1)
ENHANCED COLOR THEORY (1)
ERROR RECOVERY (1)
EUCLIDEAN DISTANCE (1)
EXCIPIENTS (1)
FILE ORGANISATION (1)
FORWARD ERROR CORRECTION (1)
FORWARD ERROR CORRECTION ALGORITHM (1)
HEURISTIC ALGORITHMS (1)
HIERARCHICAL SOCIAL NETWORK-BASED P2P SIP SYSTEM (1)
HISTONE DEACETYLASE INHIBITORS (1)
HYDRATE (1)
I/O WELLS PLACEMENT (1)
INDOLE (1)
INTERACTION POTENTIAL (1)
INTERPOLATION (1)
IONIZATION STATE (1)
IP NETWORKS (1)
JOINING PROCESSES (1)
LAB-ON-A-CHIP (1)
LABORATORIES (1)
LARYNGEAL ELECTROMYOGRAPHY (1)
LOCALIZATION (1)
MATHEMATICAL MODELLING (1)
MESH BASED ARCHITECTURE (1)
MICAZ MOTE DEVELOPER'S KIT (1)
MICROCHIP BASED CAPILLARY ELECTROPHORESIS CHANNEL SYSTEMS (1)
MICROFLUIDIC BIOCHIPS (1)
MICROFLUIDICS (1)
MIXERS (1)
MIXING ALGORITHM (1)
MOBILE COMMUNICATION (1)
MOBILE COMPUTING (1)
MOBILE ENVIRONMENT (1)
MOBILE POSITIONING (1)
MOBILE RADIO (1)
MOBILE WIRELESS SENSOR NETWORKS (1)
MOBILITY PREDICTION (1)
MOISTURE SORPTION (1)
MONTE CARLO LOCALIZATION (1)
MONTE CARLO METHODS (1)
MOVING SIMILARITY (1)
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INFONA - science communication portal

Search results for: Yi-Ling Hsieh

Postirradiated carotid blowout syndrome in patients with nasopharyngeal carcinoma: A case–control study

Salt Stability – The Effect of pH_max on Salt to Free Base Conversion

Salt Stability - Effect of Particle Size, Relative Humidity, Temperature and Composition on Salt to Free Base Conversion

Indole-3-ethylsulfamoylphenylacrylamides: Potent histone deacetylase inhibitors with anti-inflammatory activity

Assessing the Impact of Polymers on the pH‐Induced Precipitation Behavior of Poorly Water Soluble Compounds using Synchrotron Wide Angle X‐Ray Scattering

Laryngeal electromyography findings of vocal fold immobility in patients after radiotherapy for nasopharyngeal carcinoma

Impact of sertraline salt form on the oxidative stability in powder blends

Biochip Synthesis and Dynamic Error Recovery for Sample Preparation Using Digital Microfluidics

Classification of the Crystallization Behavior of Amorphous Active Pharmaceutical Ingredients in Aqueous Environments

A road-based QoS-aware multipath routing for urban vehicular ad hoc networks

Dynamic overlay multicast for live multimedia streaming in urban VANETs

Design methodology for sample preparation on digital microfluidic biochips

A Reagent-Saving Mixing Algorithm for Preparing Multiple-Target Biochemical Samples Using Digital Microfluidics

pH-Induced Precipitation Behavior of Weakly Basic Compounds: Determination of Extent and Duration of Supersaturation Using Potentiometric Titration and Correlation to Solid State Properties

On-chip biochemical sample preparation using digital microfluidics

A reliable routing scheme based on vehicle moving similarity for VANETs

Complex dielectric properties of microcrystalline cellulose, anhydrous lactose, and α‐lactose monohydrate powders using a microwave‐based open‐reflection resonator sensor

Road Layout Adaptive Overlay Multicast for Urban Vehicular Ad Hoc Networks

Automated Physical Design of Microchip-Based Capillary Electrophoresis Systems

Efficient Color-theory-based Dynamic Localization for Mobile Wireless Sensor Networks

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