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The integration of biosensors, microfluidics and CMOS instrumentation provides a compact lab-on-CMOS microsystem well suited for high throughput measurement. This paper describes a screen-printed planar metallization technique for lab-on-CMOS that overcomes challenges associated with traditional thin film metallization. Utilizing a chip-in-carrier packaging approach with an epoxy carrier, screen-printed...
Integrated sensor arrays on CMOS instrumentation chips are attractive to many biological and biomedical sensor applications. However, the packaging of CMOS circuitry for use within a liquid environment remains as an open challenge. Reliable post-CMOS electrode fabrication and packaging processes that are critical to the development of integrated electrochemical biosensors are presented in this paper...
An integrated CMOS amperometric instrument with on-chip electrodes and packaging for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in CMOS, the chip dissipates 22.5 mW for a 200 kHz clock. The...
The opportunity to integrate microfluidic devices with CMOS instrumentation is attractive to many biological and biomedical sensor applications. However, the packaging of CMOS circuitry for use within a liquid environment remains as an open challenge. This paper presents a robust and reliable packaging scheme for on-CMOS biosensors that is uniquely capable of providing both electrical insulation of...
An integrated amperometric instrumentation system with on-chip electrodes for biosensor arrays is presented. The mixed-signal integrated circuit supports a variety of electrochemical measurement techniques including linear sweep, constant potential, cyclic and pulse voltammetry. Implemented in 0.5 μm CMOS, the 3×3 mm2 chip dissipates 22.5 mW for a 200 kHz clock. The highly programmable chip provides...
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