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Oncolytic virotherapy is one of promising tumor therapy modalities. However, its therapeutic efficacy is still limited due to the immunogenicity and poor tumor-targeting capability. In this report, an engineered oncolytic vaccinia virus (OVV) was constructed by site-specifically introducing azide groups to the envelope of OVV during the in situ assembling process of virions. Subsequently, dibenzocyclooctynes...
The hydraulic simulation is an important work in the design and construction of gas pipeline network in the city. It is also a necessary means to improve pipeline network, optimize the operation and management of pipe network, and ensure the safety of gas supply. In this paper, based on the model of hydraulic calculation and the finite element nodal method, the research on the hydraulic simulation...
In the paper, a nonlinear method is presented which is used to analyse the phase noise of RF and microwave oscillators in the time domain. It leads to exact design rules and provides us with the design guide for the key components of the oscillator. A circuit simulation at 1GHz is presented to confirm the theoretical results. The simulation and optimization of the oscillator are carried out with Advanced...
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