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Our body motion is adjusted properly under 1G on the earth. Thus changes in gravitational environment have significant impact on our motor control. Further, it may affect on our ability in motor learning and memory. Although some astronauts informally reported difficulties in their body control under microgravity, no quantitative research on this issue has been conducted. Here we performed the prism...
The total synthesis of lactonamycin has been achieved. The synthesis includes sequential intramolecular conjugate addition of alcohols to the acetylenic ester, stereoselective glycosylation of the tertiary alcohol, and Michael–Dieckmann type cyclization with the thioester, by which the highly convergent route has been established.
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