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The mutation of the Parkin gene is a cause of familial Parkinson’s disease. A growing body of evidence suggests that Parkin also functions as a tumor suppressor. Parkin is an ubiquitin E3 ligase, and plays important roles in a variety of cellular processes implicated in tumorigenesis, including cell cycle, cell proliferation, apoptosis, metastasis, mitophagy and metabolic reprogramming. Here we review...
Tumor suppressor p53 plays a central role in tumor suppression. As a transcription factor, p53 mainly exerts its tumor suppressive function through transcriptional regulation of many target genes. To maintain the proper function of p53, p53 protein level and activity are exquisitely controlled by a group of positive and negative regulators in cells. Thus, p53, its regulators, and regulated genes...
Accurately predicting the risk of cancer recurrence and metastasis is critical to cancer individualized treatment. Currently, physicians commonly use histological grade, which is determined by pathologists via performing a semi-quantitative analysis of three histological and cytological features on Hematoxylin-Eosin (HE) stained histopathological images, to assess the prognosis of a breast cancer...
Along with the emergence and development of translational biomedicine, more and more genetic information has been applied in clinical practice. In recent decade, the discovery of genetic biomarkers for cancer prognosis obtains increasing attentions and many methods have been developed. The "element" methods use one or two independent genes to judge the Boolean status of disease. The "set"...
The cancer classification is a major and important study field in the medical research, and DNA microarrays have been proved to provide useful and great information for cancer classification at molecular level, compared with traditional clinical or histopathological information. Bio-markers from microarray gene expression analysis have developed to a new approach for cancer classification but still...
In clinical applications, such as breast cancer prognosis, many classical factors are generally considered not to be sufficient for our need. Along with micro-arrays have had a great impact on cancer research in the past decade, new and more powerful gene biomarkers are discovered. And advanced prognostic index are still called for yet. In another way, currently many classification method/strategy,...
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