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This study was performed to investigate whether or not the histamine H 3 -antagonist clobenpropit can ameliorate spatial memory deficits induced by MK-801 (0.3μg per site) as evaluated by an eight-arm radial maze task of rats. A bilateral intrahippocampal (i.h.) injection of clobenpropit (5, 10μg per site, dose-dependent) markedly improved the working and reference memory deficits induced...
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