Search results for: M S Kumar

Items from 1 to 20 out of 20 results

article

Anti‐proliferative and anti‐malarial activities of spiroisoxazoline analogues of artemisinin

Surya Pratap, Fatima Naaz, Srinivas Reddy, Kunal K. Jha, more

Archiv der Pharmazie > 352 > 1 > n/a - n/a

A series of spiroisoxazoline analogues of artemisinin was synthesized by employing 1,3‐dipolar cycloaddition between various in situ generated nitrile oxides and artemisitene. All the synthesized compounds were tested for their anti‐proliferative and anti‐malarial activities. Among the compounds tested, compound 11a was found to be potent against the HCT‐15 cancer cell line with IC₅₀ = 4.04 μM when...

article

Perceptions of Barriers Towards Active Surveillance for Low-Risk Prostate Cancer: Results From a National Survey of Radiation Oncologists and Urologists

Simon P. Kim, Cary P. Gross, Nilay D. Shah, Jon. C. Tilburt, more

Annals of Surgical Oncology > 2019 > 26 > 2 > 660-668

Purpose The reasons for low clinical adoption of active surveillance (AS) for low-risk prostate cancer (PCa) remain poorly understood. Thus, we conducted a national survey of radiation oncologists (ROs) and urologists (UROs) to elucidate perceived barriers to AS for low-risk PCa. Methods In 2017, we undertook a four-wave mail survey of 1855 ROs and UROs. The survey instrument assessed attitudes...

article

Postoperative hypofractionated stereotactic brain radiation (HSRT) for resected brain metastases: improved local control with higher BED₁₀

Aryavarta M. S. Kumar, Jonathan Miller, Seth A. Hoffer, David B. Mansur, more

Journal of Neuro-Oncology > 2018 > 139 > 2 > 449-454

Introduction HSRT directed to large surgical beds in patients with resected brain metastases improves local control while sparing patients the toxicity associated with whole brain radiation. We review our institutional series to determine factors predictive of local failure. Methods In a total of 39 consecutive patients with brain metastases treated from August 2011 to August 2016, 43 surgical beds...

article

Directly observed therapy of sofosbuvir/ribavirin +/− peginterferon with minimal monitoring for the treatment of chronic hepatitis C in people with a history of drug use in Chennai, India (C‐DOT)

S. S. Solomon, M. S. Sulkowski, P. Amrose, A. K. Srikrishnan, more

Journal of Viral Hepatitis > 25 > 1 > 37 - 46

We assessed the feasibility of field‐based directly observed therapy (DOT) with minimal monitoring to deliver HCV treatment to people with a history of drug use in Chennai, India. Fifty participants were randomized 1:1 to sofosbuvir+peginterferon alfa 2a+ribavirin (SOF+PR) for 12 weeks (Arm 1) vs sofosbuvir+ribavirin (SOF+R) for 24 weeks (Arm 2). SOF+R was delivered daily at participant chosen venues...

article

Neoadjuvant chemoradiation for non‐metastatic pancreatic cancer increases margin‐negative and node‐negative rates at resection

Camille A. Berriochoa, May Abdel‐Wahab, Charles M. Leyrer, Alok Khorana, more

Journal of Digestive Diseases > 18 > 11 > 642 - 649

OBJECTIVE To compare neoadjuvant to adjuvant chemoradiation in non‐metastatic pancreatic cancer patients. METHODS Single‐institution data were obtained for patients with non‐metastatic pancreatic cancer treated with concurrent chemoradiation from 2011 to 2014. Univariate analyses were performed to evaluate clinical and pathological outcomes. RESULTS Fifty‐two well‐matched patients were enrolled...

article

Radiation therapy in patients with inflammatory bowel disease and colorectal cancer: Risks and benefits

Bianca W. Chang, Aryavarta M. S. Kumar, Shlomo A. Koyfman, Matthew Kalady, more

International Journal of Colorectal Disease > 2015 > 30 > 3 > 403-408

Purpose The effects of radiotherapy are debated in inflammatory bowel disease (IBD). We examined IBD patients with colorectal cancer (CRC) and compared those who underwent external beam radiation therapy (EBRT) to those who did not. We then compared those same patients treated with EBRT to similarly treated non-IBD patients to ascertain differences in toxicity and perioperative outcomes. Methods...

article

Adjuvant chemoradiation may improve survival over adjuvant chemotherapy in resected pancreatic cancer patients who are high risk for locoregional recurrence

Aryavarta M. S. Kumar, Gavin A. Falk, Robert Pelley, R. Matthew Walsh, more

Journal of Radiation Oncology > 2015 > 4 > 3 > 271-276

Objective The objective of the study was to evaluate the benefit of adjuvant chemoradiation compared to adjuvant chemotherapy for resected pancreatic head cancer. Methods Three hundred thirty-nine patients (2000–2012) had pancreatoduodenectomy for pancreatic cancer. Chemotherapy was gemcitabine or 5-fluorouracil (5-FU) and radiotherapy was 45–54 Gy. Locoregional recurrences (LRR) were operative...

article

Growth and characterization of NLO crystal: L-leucine phthalic acid potassium iodide

M. R. Jagadeesh, H. M. S. Kumar, R. A. Kumari

Materials Science Poland > 2015 > Vol. 33, No. 3 > 529--536

A new semi-organic non linear optical crystal, L-leucine phthalic acid potassium iodide (LLPPI) has been grown from an aqueous solution by slow evaporation method. The grown crystals were subjected to different characterizations, such as single crystal XRD, FT-IR, UV-Vis, TGA, SEM, EDAX, micro hardness, dielectric and powder SHG. Single crystal structure was determined from X-ray diffraction data...

chapter

Adaptive control for interactive thermal process

R Aruna, M S Kumar

2011 International Conference on Emerging Trends in Electrical and Computer Technology > 291 - 296

2011 International Conference on Emerging Trends in Electrical and Computer Technology (ICETECT 2011)

In industries now a day the control of chemical process is important craft. Mostly all the chemical process are highly nonlinear in nature this cause instability of the process. This paper deals with basic simulation studies on of the interactive thermal process. The Combination processes of Continuous stirred tank reactor (CSTR) and heat exchanger were controlled and the mathematical model was developed...

chapter

Performance evaluation of self excited induction generator using fuzzy logic

M S Kumar, N Kumaresan, M Subbiah

India International Conference on Power Electronics 2010 (IICPE2010) > 1 - 6

2010 India International Conference on Power Electronics (IICPE)

An approach employed for the evaluation of performance of self excited induction generator (SEIG) using fuzzy logic which needs a simple modelling is proposed in this paper. In general, the conventional techniques with analytical equations are used to analyse the performance of SEIG. Here a fully fuzzy based approach is tried to evaluate the performance. The results obtained from fuzzy logic approach...

article

The metalloprotease, NN-PF3 from Naja naja venom inhibits platelet aggregation primarily by affecting α2β1 integrin

M. S. Kumar, K. S. Girish, B. S. Vishwanath, K. Kemparaju

Annals of Hematology > 2011 > 90 > 5 > 569-577

NN-PF3 is a non-toxic, anticoagulant, high-molecular-mass (67.81 kDa) metalloprotease from Indian cobra (Naja naja) venom. In the present study, NN-PF3 was investigated for the mechanism of inhibition of collagen-induced aggregation of human platelets. The complete inhibition of collagen-induced aggregation and partial inhibition of ADP- and epinephrine-induced aggregation has the respective IC₅₀...

chapter

Impact of node density on the performance of ad hoc routing protocols

M S Kumar, R Asokan

2010 IEEE International Conference on Computational Intelligence and Computing Research > 1 - 4

2010 IEEE International Conference on Computational Intelligence and Computing Research (ICCIC 2010)

An ad hoc network comprises of mobile computing devices that use wireless transmission for communication. It has no fixed infrastructure. The mobile devices also serve as routers. Ad hoc wireless networks can be deployed quickly anywhere and anytime as they eliminate the complexity of infrastructure setup. It finds applications in military communications, emergency operations, hybrid wireless network...

chapter

A novel approach for the design of controller for higher order discrete — Time systems via its reduced model

M S Kumar, N V Anand

2010 International Conference on Power, Control and Embedded Systems > 1 - 4

2010 International Conference on Power, Control and Embedded Systems (ICPCES 2010)

This paper describes a technique for designing a stabilizing controller for the stable higher order discrete-time systems via its reduced model. The reduced model is obtained by the Improved Bilinear Routh Approximation Method (IBRAM). Reduced model obtained by IBRAM is then used to determine the controller for higher order discrete-time system. It is shown that the controller which is obtained from...

chapter

Microstrip antenna for dual band/wireless application

S R Hussain, M S Kumar, D S Kumar

2010 XVth International Seminar/Workshop on Direct and Inverse Problems of Electromagnetic and Acoustic Wave Theory (DIPED) > 150 - 155

2010 XVth International Seminar/Workshop on Direct and Inverse Problems of Electromagnetic and Acoustic Wave Theory (DIPED 2010)

This paper presents a micro strip antenna for dual band wireless applications. This antenna satisfies for the frequency band (1.98 to 2.08 GHz) and (2.75 to 2.78 GHz) having return loss lower than -10 dB. At first band the return loss of the antenna is -37 dB and at second band return loss is -19 dB. The antenna is designed on a substrate with dielectric constant= 1.1. With a size 89mm×64mm×4mm the...

article

Anti-coagulant activity of a metalloprotease: further characterization from the Indian cobra (Naja naja) venom

M. S. Kumar, V. R. Devaraj, B. S. Vishwanath, K. Kemparaju

Journal of Thrombosis and Thrombolysis > 2010 > 29 > 3 > 340-348

A high molecular mass, non toxic metalloprotease the NN-PF3 with the bound Ca²⁺ and Zn²⁺ from the Naja naja venom has been studied further for its anticoagulant property. The molecular mass by MALDI-TOF mass spectrometry was 67.81 kDa. The NN-PF3 exhibited fibrin(ogen)olytic activity. In addition to fibrinogen, NN-PF3 hydrolyzed blood and plasma clot with the later hydrolyzed about one fold higher...

article

Investigation of the engine oil and biofuel based aging behavior of catalytic converters

A. Winkler, A. Ulrich, L. Emmenegger, D. Ferri, more

Prace Naukowe Instytutu Nafty i Gazu > 2010 > nr 172 > 105-112

article

Effect of Monomer Structure and Solvent on the Growth of Supramolecular Nanoassemblies on a Graphite Surface

Aryavarta M. S. Kumar, Justin D. Fox, Lauren E. Buerkle, Roger E. Marchant, more

Langmuir > 2009 > 25 > 2 > 653 - 656

article

Molecular Engineering of Supramolecular Scaffold Coatings that Can Reduce Static Platelet Adhesion

Aryavarta M. S. Kumar, Sona Sivakova, Justin D. Fox, Jennifer E. Green, more

Journal of the American Chemical Society > 2008 > 130 > 4 > 1466 - 1476

article

Molecular genetics of familial hypertrophic cardiomyopathy (FHC)

M. D. Bashyam, G. R. Savithri, M. S. Kumar, C. Narasimhan, more

Journal of Human Genetics > 2003 > 48 > 2 > 55-64

Abstract.Familial hypertrophic cardiomyopathy is an autosomal dominant disease with a wide range of clinical features from benign to severe, and is the most common cause of sudden death in otherwise healthy individuals. The two prominent clinical features are left ventricular hypertrophy and myocyte/myofibrillar disarray. The former is responsible for clinical symptoms such as breathlessness and angina,...

article

Free radical addition of haloalkanes to polymer bound olefins and its application to the solid-phase synthesis of pyrethroids

H. M. S. Kumar, P. Pawan Chakravarthy, M. Shesha Rao, P. Sunder Ram Reddy, more

Tetrahedron Letters > 2002 > 43 > 43 > 7817 - 7819

Polymer bound olefins undergo free radical initiated 1,2-addition when reacted with a variety of haloalkanes. The strategy could be applied successfully to the solid-phase synthesis of dihaloethenylcyclopropane carboxylic acids which are the key fragments of synthetic pyrethroids.

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