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Faldaprevir, a hepatitis C virus (HCV) NS3/4A protease inhibitor, was evaluated in HCV genotype 1‐infected patients who failed peginterferon and ribavirin (PegIFN/RBV) treatment during one of three prior faldaprevir trials. Patients who received placebo plus PegIFN/RBV and had virological failure during a prior trial were enrolled and treated in two cohorts: prior relapsers (n = 43) and prior nonresponders...
Experiments play an important role in parallel and distributed computing. Simulation is a common experimental technique that relies on abstractions of the tested application and execution environment but offers reproducibility of results and fast exploration of numerous scenarios. This article focuses on setting up the experimental environment of a simulation run. First we analyze the requirements...
We presented the SimGrid simulation framework whose goal is to provide a generic evaluation tool for large-scale distributed computing. Its main components are: two APIs for researchers who study algorithm and need to prototype simulations quickly, and two for developers who can develop applications in the comfort of the simulated world before deploying them seamlessly in the real world. SimGrid employs...
This paper investigate a mutual exclusion algorithm on distributed systems. We introduce a new algorithm based on the Naimi-Trehel algorithm, taking advantage of the distributed approach of Naimi-Trehel while allowing to request partial locks. Such ranged locks offer a semantic close to POSIX file locking, where threads lock some parts of the shared file. We evaluate our algorithm by comparing its...
In order to efficiently use Grid resources, users or middlewares must use some network information, and in particular some knowledge of the platform network. As such knowledge is usually not available, one must use tools which automatically build a topological network model through some measurements. Our aim is to define a methodology to assess the quality of these network model building tools, and...
This paper presents the SlMGRlD software architecture that comprises of four main components: SURF, MSG, GRAS, and SMPI. The last three components provide APIs for implementing, simulating and/or deploying distributed applications. The first component, SURF, is a fast and accurate simulation engine. The article describes all four components in terms of their goals, their usage, and their functionality,...
In this paper, we present the developments realized in the Ouragan project around the parallelization of a Matlab-like tool called Scilab. These developments use high-performance numerical libraries and different approaches based either on the duplication of Scilab processes or on computational servers. This tool, Scilab // , allows users to perform high-level operations on distributed...
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