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Medical and health data are collected and stored in various document types and databases including clinical treatment records, medical examinations, prognosis health information, health billing and claims, health surveys, and community health settings. Such huge amount, wide range, and unstructured dataset characteristics imply a big challenge for researchers and government officers to analyze and...
Proper orientation of a molecular structure in three-dimensional (3D) printing could increase successful printing rates, reduce the amount of supporting material required, and shorten printing time. In traditional approaches, manual adjustment of a target object for its optimal orientation is inefficient and inconsistent and often requires several trials. Hence, manually and visually rotated results...
Heart failure (HF) is a major public health problem with an increasing prevalence that has tremendous impact to patients all over the world. However, the signs and symptoms of HF in the early stages are not clear, so it is relatively difficult to prevent or predict. HF is also one of complicated diseases, there are yet no strict standards to classify various types of HF patients based on various tendencies...
A conformational epitope (CE) in an antigenic protein is composed of amino acid residues that are spatially near each other on the antigen's surface but discontinuously appeared in sequence. CEs bind their complementary Para topes which are located on the surface areas of B-cell receptors and/or antibodies. CE predication is a challenging research topic, which plays an important and fundamental role...
Ankyrin repeat domain (ARD) proteins contain various numbers of internal repeat units. They are considered as one important factor to influence hypoxia response through hydroxylation interaction with Factor Inhibiting HIF (FIH) enzymes which can repress HIF under normoxia environment. In this study, we adopted sequence based method and applied conserved hydroxylation motif patterns for identifying...
A novel approach based on solid angles and CUDA parallel technologies for detection of protein docking regions is proposed in this paper. A key feature of a solid angle reveals the geometrical characteristics of protein surface structures and provides an efficient criterion for identifying the anchor amino acids on surface regions. These solid angles as well as several corresponding physical properties...
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